Kim Young Mi, Lee Yoon Jin, Park Jae Hong, Lee Jun Woo, Lee Chang Hun
Department of Pediatrics, College of Medicine, Pusan National University, Pusan, Korea.
Taehan Kan Hakhoe Chi. 2002 Sep;8(3):321-6.
Idiopathic hypereosinophilic syndrome is defined as the presence of prolonged eosinophilia without an identifiable underlying cause and with evidence of end-organ dysfunction. The organs involved are the heart, bone marrow, nervous system, lungs, liver, skin, and gastrointestinal tract. Hepatic involvement is found in about 30% of patients of idiopathic hypereosinophilic syndrome. It occurs rarely in infants and children. In this report, we experienced one case of idiopathic hypereosinophilic syndrome with hepatic involvement in a 5-year-old boy who complained of intermittent fever and right upper quadrant abdominal pain. An abdominal ultrasound examination revealed an ill-defined low-echoic lesion in the liver. Pathologic findings of a biopsy specimen clearly showed the infiltration of eosinophils in the liver. Laboratory data disclosed absolute eosinophilia. There was no evidence of allergic disease or parasitic infestation.
特发性嗜酸性粒细胞增多综合征的定义为存在持续性嗜酸性粒细胞增多，且无明确的潜在病因，并伴有终末器官功能障碍的证据。受累器官包括心脏、骨髓、神经系统、肺、肝、皮肤和胃肠道。约30%的特发性嗜酸性粒细胞增多综合征患者存在肝脏受累。在婴儿和儿童中很少发生。在本报告中，我们遇到一例5岁男孩特发性嗜酸性粒细胞增多综合征伴肝脏受累，该男孩主诉间歇性发热和右上腹腹痛。腹部超声检查显示肝脏有边界不清的低回声病变。活检标本的病理结果清楚地显示肝脏中有嗜酸性粒细胞浸润。实验室数据显示绝对嗜酸性粒细胞增多。没有过敏性疾病或寄生虫感染的证据。
