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心脏手术后的胃肠道并发症:全面综述

Gastrointestinal complications following cardiac surgery: a comprehensive review.

作者信息

Rodriguez Roberto, Robich Michael P, Plate Juan F, Trooskin Stanley Z, Sellke Frank W

机构信息

Division of Cardiothoracic Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.

出版信息

J Card Surg. 2010 Mar;25(2):188-97. doi: 10.1111/j.1540-8191.2009.00985.x. Epub 2010 Feb 9.

Abstract

INTRODUCTION

Gastrointestinal (GI) complications following cardiac surgery are associated with a high morbidity and mortality, prolonged hospital stay and increased cost of hospitalization.

METHODS

A literature search was carried out using Medline for articles published in the past 30 years. Prospective and retrospective papers that dealt with coronary artery bypass grafting (CABG), CABG/valve operations were selected and those that dealt with thoracic and transplant complications were excluded.

RESULTS

We reviewed 151,652 patients reported over the past 30 years; GI complications occurred on average after 1.21% of cardiac operations and had an associated mortality of 34.1%. The most common risk factors identified include age greater than 70 years, low cardiac output, peripheral vascular disease, reoperative surgery, chronic renal insufficiency, increased number of blood transfusions, prolonged cardiopulmonary bypass time, arrhythmias, and use of an intraaortic balloon pump. A critical examination of the available literature revealed multifactorial etiologies (often related to hypoperfusion) leading to GI complications. Delayed diagnosis was associated with poor outcomes.

CONCLUSION

GI complications are rare events, but early diagnosis is essential. Unfortunately few of the risk factors we have defined are specific and are often indicators of ill patients. A low threshold to initiate laboratory evaluation and/or imaging studies should be employed if a patient shows signs of deviating from the normal course following cardiac surgery.

摘要

引言

心脏手术后的胃肠道(GI)并发症与高发病率、高死亡率、住院时间延长及住院费用增加相关。

方法

使用Medline对过去30年发表的文章进行文献检索。选择涉及冠状动脉旁路移植术(CABG)、CABG/瓣膜手术的前瞻性和回顾性论文,排除涉及胸科和移植并发症的论文。

结果

我们回顾了过去30年报告的151,652例患者;GI并发症平均发生在1.21%的心脏手术之后,相关死亡率为34.1%。确定的最常见风险因素包括年龄大于70岁、心输出量低、外周血管疾病、再次手术、慢性肾功能不全、输血次数增加、体外循环时间延长、心律失常以及使用主动脉内球囊泵。对现有文献的严格审查显示,导致GI并发症的病因是多因素的(通常与灌注不足有关)。诊断延迟与不良预后相关。

结论

GI并发症是罕见事件,但早期诊断至关重要。不幸的是,我们确定的风险因素中很少有特异性的,且往往是病情严重患者的指标。如果患者在心脏手术后出现偏离正常病程的迹象,应采用较低阈值启动实验室评估和/或影像学检查。

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