Ugaki Hiromi, Enomoto Takayuki, Tokugawa Yoshihiro, Kimura Tadashi
Department of Obstetrics and Gynecology, Osaka University, Graduate School of Medicine, Osaka, Japan.
J Obstet Gynaecol Res. 2009 Oct;35(5):991-3. doi: 10.1111/j.1447-0756.2009.01046.x.
A pregnancy luteoma represents an unusual response of ovarian stromal cells to the altered hormonal levels of pregnancy. It is a distinctive non-neoplastic lesion characterized by solid proliferations of luteinized cells resulting in a tumor-like ovarian enlargement. Most patients are asymptomatic; the ovarian enlargement is usually discovered incidentally at cesarean section or during postpartum tubal ligation. We report a typical case that we found at cesarean section to be associated with a virilized infant who manifested clitoromegaly and labial fusion. We detected an increased level of testosterone in the maternal patient. We concluded that the ovarian luteoma induced the fetal virilization.
妊娠黄体瘤是卵巢基质细胞对妊娠期间激素水平变化的一种异常反应。它是一种独特的非肿瘤性病变，其特征是黄体化细胞的实性增生，导致卵巢呈肿瘤样增大。大多数患者无症状；卵巢增大通常在剖宫产或产后输卵管结扎时偶然发现。我们报告一例典型病例，在剖宫产时发现与一名男性化婴儿相关，该婴儿表现为阴蒂肥大和阴唇融合。我们检测到产妇患者的睾酮水平升高。我们得出结论，卵巢黄体瘤导致了胎儿男性化。
