促性腺激素释放激素拮抗剂加尼瑞克未能阻断外源性雌激素对正常女性的正反馈效应。
Failure of the GnRH antagonist ganirelix to block the positive feedback effect of exogenous estrogen in normal women.
机构信息
Department of Obstetrics and Gynecology, Medical School, University of Thessalia, Larissa, Greece.
Department of Obstetrics and Gynecology, Medical School, University of Thessalia, Larissa, Greece.
出版信息
Fertil Steril. 2010 Sep;94(4):1554-1556. doi: 10.1016/j.fertnstert.2009.12.055. Epub 2010 Feb 10.
Abstract
This study investigated whether the GnRH antagonist ganirelix is able to block the positive-feedback effect of E2 in normal women. Ganirelix was unable to block the positive-feedback effect, suggesting that the clinical efficacy of GnRH antagonists in IVF cycles is determined by the hyperstimulation process.
摘要
本研究旨在探讨 GnRH 拮抗剂加尼瑞克是否能够阻断正常女性体内 E2 的正反馈效应。加尼瑞克未能阻断正反馈效应，这表明 GnRH 拮抗剂在 IVF 周期中的临床疗效取决于超刺激过程。
Zotero 插件