Bio-X Center, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, PR China.
J Psychiatr Res. 2010 Apr;44(6):409-12. doi: 10.1016/j.jpsychires.2009.10.009. Epub 2010 Feb 9.
Choudhury et al. identified FXYD6 as a susceptible gene for schizophrenia in the London and Aberdeen populations. We genotyped D11S1998 and 8 SNPs (rs869789, rs11216567, rs10790212, rs876797, rs4938445, rs497768, rs11216598, rs11605223) in a Chinese sample consisting of 1514 schizophrenia patients and 1514 healthy controls. We also compared the expression levels of FXYD6 in lymphocytes in 86 schizophrenia patients and 94 controls. No association was detected either in D11S1998 or the 8 SNPs. No difference was found in expression level between patients and controls. Our study suggests that FXYD6 does not play a role in schizophrenia in the Chinese Han population.
Choudhury 等人在伦敦和阿伯丁人群中发现 FXYD6 是精神分裂症的易感基因。我们对一个由 1514 名精神分裂症患者和 1514 名健康对照组成的中国样本进行了 D11S1998 和 8 个 SNP（rs869789、rs11216567、rs10790212、rs876797、rs4938445、rs497768、rs11216598、rs11605223）的基因分型。我们还比较了 86 名精神分裂症患者和 94 名对照者淋巴细胞中 FXYD6 的表达水平。在 D11S1998 或 8 个 SNP 中均未检测到相关性。患者和对照组之间的表达水平没有差异。我们的研究表明，FXYD6 在中国汉族人群中与精神分裂症无关。
