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一些缩合的[4-(3,4-二甲基苯基)-1(2H)-氧代-酞嗪-2-基]乙酸酰肼的合成及抗炎活性评价。

Synthesis and anti-inflammatory evaluation of some condensed [4-(3,4-dimethylphenyl)-1(2H)-oxo-phthalazin-2-yl]acetic acid hydrazide.

机构信息

Pharmaceutical organic chemistry Department, Faculty of Pharmacy, Helwan University, Ain Helwan, Cairo, Egypt.

出版信息

Eur J Med Chem. 2010 Apr;45(4):1267-77. doi: 10.1016/j.ejmech.2009.10.028. Epub 2009 Oct 23.

DOI:10.1016/j.ejmech.2009.10.028
PMID:20149488
Abstract

Some new 1,3,4-triazolo-, 1,3,4-oxadiazolo-, 1,3,4-thiadiazol-, and pyrazolo-3,4-dimethylphenyl-1(2H)-oxo-phthalazine derivatives were synthesized and identified by IR, (1)H NMR, MS and elemental analysis. Most of the newly synthesized products were tested for their anti-inflammatory activities. Among them, compounds 11, 17b, 20, 21 and 22 are active compare to the activity of indomethacin.

摘要

一些新的 1,3,4-三唑、1,3,4-噁二唑、1,3,4-噻二唑和吡唑并[3,4-d]甲基苯基-1(2H)-氧代-酞嗪衍生物被合成并通过红外光谱（IR）、核磁共振氢谱（1H NMR）、质谱（MS）和元素分析进行了鉴定。大多数新合成的产物都进行了抗炎活性测试。其中，化合物 11、17b、20、21 和 22 的活性与吲哚美辛相当。

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