Department of Chemical Physics, Weizmann Institute of Science, Rehovot 76100, Israel.
J Magn Reson. 2010 Apr;203(2):311-5. doi: 10.1016/j.jmr.2009.10.013. Epub 2009 Nov 3.
A new scheme for the acquisition of heteronuclear 2D correlations in NMR spectroscopy within a single scan, is proposed and demonstrated. The principles of this new scheme resemble those of Mansfield's "k-space walk" proposal, in the sense that they rely on repetitively transferring spin coherences back-and-forth between the two spin systems to be correlated. It is shown that if properly executed, these transfers enable the equivalent of a continuous sampling of the time-domain space supporting a 2D heteronuclear single-quantum correlation NMR spectrum. Details on how to execute the resulting "time-domain walk" experiments are given, and examples comparing it against conventional and other single-scan 2D acquisition alternatives are shown. Advantages, opportunities, and main drawbacks of this new ultrafast approach to 2D NMR, are briefly discussed.
提出并证明了一种在单个扫描中获取 NMR 光谱中异核二维相关的新方案。该新方案的原理类似于 Mansfield 的“k 空间漫步”方案，因为它们都依赖于反复在要相关的两个自旋系统之间来回转移自旋相干性。结果表明，如果执行得当，这些转移可以等效于对支持二维异核单量子相关 NMR 谱的时域空间进行连续采样。给出了如何执行由此产生的“时域漫步”实验的详细信息，并展示了与传统和其他单扫描 2D 采集替代方案的比较示例。简要讨论了这种新的二维 NMR 超快方法的优点、机会和主要缺点。
