Nox 蛋白源性活性氧在脉管系统中的同种型特异性功能。

Isoform specific functions of Nox protein-derived reactive oxygen species in the vasculature.

机构信息

Institut für Kardiovaskuläre Physiologie, Fachbereich Medizin der Goethe-Universität, Theodor-Stern Kai 7, 60596 Frankfurt am Main, Germany.

出版信息

Curr Opin Pharmacol. 2010 Apr;10(2):122-6. doi: 10.1016/j.coph.2010.01.002. Epub 2010 Feb 10.

DOI:10.1016/j.coph.2010.01.002

PMID:20149739

Abstract

The family of NADPH oxidases consists of seven members that are all producing reactive oxygen species (ROS). In the cardiovascular systems three NADPH oxidases are expressed: Nox1, Nox2 and Nox4, which all exhibit different physiological functions such as regulating blood pressure, mediating growth factor signaling and controlling cell proliferation. In this article the recent research concerning the specificity and function mediated by NADPH oxidases will be reviewed.

摘要

NADPH 氧化酶家族由 7 个成员组成，它们都能产生活性氧（ROS）。在心血管系统中，有三种 NADPH 氧化酶表达：Nox1、Nox2 和 Nox4，它们都具有不同的生理功能，如调节血压、介导生长因子信号转导和控制细胞增殖。本文将综述 NADPH 氧化酶介导的特异性和功能的最新研究进展。