Department of Microelectronics, Faculty of Electrical Engineering and Communication, Brno University of Technology, 602 00 Brno, Czech Republic.
Pharmacol Res. 2010 Aug;62(2):144-9. doi: 10.1016/j.phrs.2010.01.014. Epub 2010 Feb 10.
Magnetic nanoparticles (MNPs) are being of great interest due to their unique purposes. Especially in medicine, application of MNPs is much promising. MNPs have been actively investigated as the next generation of targeted drug delivery for more than thirty years. The importance of targeted drug delivery and targeted drug therapy is to transport a drug directly to the centre of the disease under various conditions and thereby treat it deliberately, with no effects on the body. Usage of MNPs depends largely on the preparation processes to select optimal conditions and election agents to modify their surface. This review summarizes the most commonly used functionalization methods of the MNPs preparation methods and their use in targeted drug delivery and targeted therapy.
磁性纳米粒子（MNPs）由于其独特的用途而备受关注。特别是在医学领域，MNPs 的应用前景非常广阔。MNPs 作为下一代靶向药物输送系统已经得到了三十多年的积极研究。靶向药物输送和靶向治疗的重要性在于，在各种条件下将药物直接输送到疾病中心，从而有针对性地进行治疗，而不会对身体产生影响。MNPs 的使用在很大程度上取决于制备工艺来选择最佳条件和选择试剂来修饰其表面。本文综述了 MNPs 制备方法中最常用的功能化方法及其在靶向药物输送和靶向治疗中的应用。
