The University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School at Camden, Cooper Hospital University Medical Center, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Camden, NJ, USA.
Anticancer Res. 2010 Jan;30(1):119-22.
There are data showing that human leukemia cell lines have mRNA for an immunomodulatory protein found in normal pregnancy that is stimulated by progesterone. One of the functions of this progesterone-induced blocking factor (PIBF) is to suppress natural killer cell activity. Mifepristone has not only been shown to down-regulate PIBF expression by human leukemic cell lines but has also been shown to prolong and improve the length of life of mice with spontaneous leukemia.
Mifepristone at 0.3 mg was gavaged three times weekly from 8 weeks vs. olive oil in the controls.
The survival at one year for mice treated with mifepristone was 57.6% vs. 26.6% for controls (p=0.056). There were 66.7% of mice treated with mifepristone with no sick days whereas there was not one control mouse that did not become sick within the first year. The mean number of days sick was 11.6 for mifepristone vs. 57.6 days for controls (p=0.05) and 66.7% of the survival group had no sick days vs. none of the controls.
These data suggest a possible novel cancer therapy using progesterone receptor antagonist drugs even in tumors not known to have progesterone receptors to try to change the tumor microenvironment and re-activate suppressed natural killer cells.
有数据表明，人类白血病细胞系存在一种在正常妊娠中发现的免疫调节蛋白的 mRNA，该蛋白受到孕激素的刺激。这种孕激素诱导的阻断因子（PIBF）的功能之一是抑制自然杀伤细胞的活性。米非司酮不仅显示出通过人白血病细胞系下调 PIBF 表达，而且还显示出延长和改善自发性白血病小鼠的寿命。
从第 8 周开始，每周三次通过灌胃给予米非司酮 0.3mg，与对照组中的橄榄油进行比较。
接受米非司酮治疗的小鼠在一年内的存活率为 57.6%，而对照组为 26.6%（p=0.056）。接受米非司酮治疗的小鼠中有 66.7%没有生病的日子，而对照组中没有一只老鼠在第一年不生病。米非司酮组生病的平均天数为 11.6 天，而对照组为 57.6 天（p=0.05），并且在存活组中，有 66.7%的小鼠没有生病的日子，而对照组中没有一只老鼠。
这些数据表明，即使在未知具有孕激素受体的肿瘤中，使用孕激素受体拮抗剂药物也可能是一种新的癌症治疗方法，试图改变肿瘤微环境并重新激活被抑制的自然杀伤细胞。
