Demin N N, Guterman E E, Kudriavtseva G V, Panov A N, Rashevskaia D A
Fiziol Zh SSSR Im I M Sechenova. 1977 Nov;63(11):1524-8.
The selective paradoxical sleep (PS) deprivation in rats entailed during first 2 days a drop in activity of glucose-6-phosphatehydrogenase by 80 and 60%, and of 6-phosphogluconatdehydrogenase -- by 20--35 and 40--50% in the brain-stem and the cortex, respectively. Activity of the transketolase decreased by 27--29% on the 2nd day of PS deprivation only. On the 4th day, normalizing of activity of all the enzymes under study except transketolase, was observed in both regions of the brain. The consumption of riboso-5-phosphate by the homogenate and level of phosphoketopentoses formation in it reflected, mainly, the dynamics of transketolase activity changes.
大鼠选择性异相睡眠（PS）剥夺在最初两天导致脑干和皮层中葡萄糖-6-磷酸脱氢酶的活性分别下降80%和60%，6-磷酸葡萄糖酸脱氢酶的活性分别下降20% - 35%和40% - 50%。仅在PS剥夺的第2天，转酮醇酶的活性下降了27% - 29%。在第4天，除转酮醇酶外，在大脑的两个区域均观察到所有研究酶的活性恢复正常。匀浆对5-磷酸核糖的消耗及其磷酸酮戊糖的形成水平主要反映了转酮醇酶活性变化的动态。
