锝-99m 半胱氨酸乙酯二聚体（ECD）在甲状腺功能减退症期间的脑内蓄积及症状和体征严重程度。
Technetium-99m ethyl cysteinate dimer (ECD) cerebral accumulation and symptom and sign severity during hypothyroidism.
作者信息
Schraml Frank V, Beason-Held Lori L
机构信息
Department of Radiology, Saint Joseph's Hospital and Medical Center and The Barrow Neurologic Institute; 350 West Thomas Rd., Phoenix, Arizona, USA.
出版信息
Neuro Endocrinol Lett. 2010;31(1):161-7.
OBJECTIVE
The purpose of this study was to correlate hypothyroid-related symptomatology with regional cerebral blood flow (rCBF) during hypothyroidism.
MATERIALS AND METHODS
Nine thyroidectomized patients underwent neuropsychological testing and single photon emission computed tomography (SPECT) of their brains with technetium-99m (Tc-99m) ethyl cysteinate dimer (ECD), a lipophilic cerebral blood flow radiotracer, while hypothyroid, and again following thyroid hormone replacement. Neuropsychological test scores and TSH levels while hypothyroid were correlated with rCBF in hypothyroid-affected areas of the brain.
RESULTS
Correlations were found during hypothyroidism between the noted parameters and ECD radiotracer accumulation in the following respective regions, all of which demonstrated hypothyroid-related cerebral blood flow (CBF) aberrations: TSH and left middle occipital gyrus; psychomotor performance speed and left precentral gyrus; and depression and right middle frontal gyrus, left middle frontal gyrus, right insula, and left thalamus.
CONCLUSIONS
Severity of psychomotor impairment and depression, and TSH level during hypothyroidism appeared to correlate with CBF to brain regions associated with motor activity, mood and vision, respectively; and previously shown to manifest significantly altered rCBF during hypothyroidism.
目的
本研究旨在探讨甲状腺功能减退症期间甲状腺功能减退相关症状与局部脑血流量（rCBF）之间的关系。
材料与方法
9例甲状腺切除患者在甲状腺功能减退时，接受了神经心理学测试以及使用锝-99m（Tc-99m）乙胱氨酸二聚体（ECD，一种亲脂性脑血流放射性示踪剂）进行的脑单光子发射计算机断层扫描（SPECT），甲状腺激素替代治疗后再次进行上述检查。甲状腺功能减退时的神经心理学测试分数和促甲状腺激素（TSH）水平与大脑甲状腺功能减退影响区域的rCBF相关。
结果
在甲状腺功能减退期间，发现以下各区域中上述参数与ECD放射性示踪剂积聚之间存在相关性，所有这些区域均显示出与甲状腺功能减退相关的脑血流量（CBF）异常：TSH与左侧枕中回；精神运动表现速度与左侧中央前回；抑郁与右侧额中回、左侧额中回、右侧岛叶和左侧丘脑。
结论
甲状腺功能减退期间精神运动障碍和抑郁的严重程度以及TSH水平似乎分别与与运动活动、情绪和视觉相关的脑区的CBF相关；并且先前已表明在甲状腺功能减退期间这些脑区的rCBF有显著改变。
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