Krausz Yodphat, Freedman Nanette, Lester Hava, Barkai Gavriel, Levin Tomer, Bocher Moshe, Chisin Roland, Lerer Bernard, Bonne Omer
Department of Medical Biophysics and Nuclear Medicine, Hadassah - Hebrew University Medical Center, Jerusalem, Israel.
Int J Neuropsychopharmacol. 2007 Feb;10(1):99-106. doi: 10.1017/S1461145706006481. Epub 2006 May 4.
Hypothyroidism and major depressive disorder (MDD) share neuropsychiatric features. Cerebral perfusion deficits are found in both disorders. We compared regional cerebral blood flow (rCBF) in hypothyroidism and MDD to determine if clinical similarities are mediated by common neurocircuitry. Ten hypothyroid and 10 depressed patients underwent 99mTc-HMPAO-SPECT and clinical evaluation before and after response to respective treatments. Ten healthy controls underwent a similar, single, evaluation. Before treatment, rCBF in hypothyroid and depressed patients was lower than in controls, in posterior and anterior aspects of the brain respectively. rCBF in hypothyroidism was lower than in MDD in right posterior cingulate and parieto/occipital regions, and higher in frontal, prefrontal and sub-genual regions. Reduced rCBF in pre- and post-central gyri was found in both groups. Following treatment, rCBF in depressed patients increased and normalized, but remained unchanged in hypothyroidism. Affective symptoms in hypothyroidism may be mediated by neurocircuitry different from that of major depression.
甲状腺功能减退症与重度抑郁症（MDD）具有共同的神经精神特征。两种疾病均存在脑灌注不足。我们比较了甲状腺功能减退症和MDD患者的局部脑血流量（rCBF），以确定临床相似性是否由共同的神经回路介导。10名甲状腺功能减退症患者和10名抑郁症患者在接受各自治疗前后分别进行了99mTc-HMPAO-SPECT检查和临床评估。10名健康对照者进行了类似的单次评估。治疗前，甲状腺功能减退症患者和抑郁症患者的rCBF分别在大脑后部和前部低于对照组。甲状腺功能减退症患者在右侧后扣带回和顶叶/枕叶区域的rCBF低于MDD患者，而在额叶、前额叶和膝下区域则较高。两组患者的中央前回和中央后回rCBF均降低。治疗后，抑郁症患者的rCBF增加并恢复正常，但甲状腺功能减退症患者的rCBF保持不变。甲状腺功能减退症的情感症状可能由与重度抑郁症不同的神经回路介导。
