环磷酸腺苷对大鼠神经垂体离体释放抗利尿激素的抑制作用。
Inhibitory effects of cyclic AMP on vasopressin release from the rat neural lobe in vitro.
作者信息
Mathison R, Lederis K
出版信息
Mol Cell Endocrinol. 1977 Nov;9(1):81-9. doi: 10.1016/0303-7207(77)90048-x.
PMID:201516
Abstract
The basal release of vasopressin from the isolated neural lobe of the rat decreased in the presence of exogenous cAMP, 8Br-cAMP, diB-cAMP, theophylline, SQ 20,009 and RO20-1724. The concentration-related decrease in vasopressin release, in the presence of phosphodiesterase inhibitors, was accompanied by a progressive increase in cAMP concentration in the neural lobe. The findings suggest a local modulation of vasopressin release from the neural lobes.
摘要
在存在外源性环磷酸腺苷（cAMP）、8-溴环磷酸腺苷（8Br-cAMP）、二丁酰环磷酸腺苷（diB-cAMP）、茶碱、SQ 20,009和RO20-1724的情况下，大鼠离体神经垂体中抗利尿激素的基础释放量减少。在磷酸二酯酶抑制剂存在的情况下，抗利尿激素释放量的浓度相关性降低伴随着神经垂体中cAMP浓度的逐渐升高。这些发现提示神经垂体中抗利尿激素释放存在局部调节。
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