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鼻内咪达唑仑镇静联合一氧化二氮与氧气吸入镇静在儿科牙科患者中作为全身麻醉替代方法的安全性和有效性。

The safety and efficacy of intranasal midazolam sedation combined with inhalation sedation with nitrous oxide and oxygen in paediatric dental patients as an alternative to general anaesthesia.

作者信息

Wood Michael

机构信息

Specialist in Special Care Dentistry, Leagrave Dental Anaesthetic Clinic, Luton, Bedfordshire.

出版信息

SAAD Dig. 2010 Jan;26:12-22.

Abstract

INTRODUCTION

Conscious Decision' was published in 2000 by the Department of Health, effectively ending the provision of dental general anaesthesia (DGA) outside the hospital environment. Other aspects of dental anxiety and behavioural management and sedation techniques were encouraged before the decision to refer for a DGA was reached. Although some anxious children may be managed with relative analgesia (RA), some may require different sedation techniques for dentists to accomplish dental treatment. Little evidence has been published in the UK to support the use of alternative sedation techniques in children. This paper presents another option using an alternative conscious sedation technique.

AIM

to determine whether a combination of intranasal midazolam (IN) and inhalation sedation with nitrous oxide and oxygen is a safe and practical alternative to DGA.

STUDY DESIGN

A prospective clinical audit of 100 cases was carried out on children referred to a centre for DGA.

METHOD

100 children between 3 and 13 years of age who were referred for DGA were treated using this technique. Sedation was performed by intranasal midazolam followed by titrating a mixture of nitrous oxide and oxygen. A range of dental procedures was carried out while the children were sedated. Parents were present during the dental treatment. Data related to the patient, dentistry and treatment as well as sedation variables were collected at the treatment visit and a telephonic post-operative assessment from the parents was completed a week later.

RESULTS

It was found that 96% of the required dental treatment was completed successfully using this technique, with parents finding this technique acceptable in 93% of cases. 50% of children found the intranasal administration of the midazolam acceptable. There was no clinically relevant oxygen desaturation during the procedure. Patients were haemodynamically stable and verbal contact was maintained throughout the procedure.

CONCLUSIONS

In selected cases this technique provides a safe and effective alternative to DGA and could reduce the number of patients referred to hospitals for DGA. It is recommended that this technique should only be used by dentists skilled in sedation with the appropriate staff and equipment at their disposal.

摘要

引言

《有意识的决定》于2000年由卫生部发布,实际上终结了在医院环境之外提供牙科全身麻醉(DGA)的做法。在决定转诊进行DGA之前,鼓励先采用牙科焦虑及行为管理和镇静技术的其他方面。尽管一些焦虑的儿童可以通过相对镇痛(RA)进行管理,但有些儿童可能需要不同的镇静技术,以便牙医完成牙科治疗。在英国,几乎没有证据支持在儿童中使用替代镇静技术。本文介绍了另一种使用替代清醒镇静技术的选择。

目的

确定鼻内咪达唑仑(IN)与氧化亚氮和氧气吸入镇静相结合是否是DGA的一种安全实用的替代方法。

研究设计

对转诊至一个DGA中心的100例儿童进行了前瞻性临床审计。

方法

对100名年龄在3至13岁之间转诊进行DGA的儿童采用该技术进行治疗。先通过鼻内给予咪达唑仑进行镇静,然后滴定氧化亚氮和氧气的混合物。在儿童镇静期间进行了一系列牙科手术。牙科治疗期间家长在场。在治疗就诊时收集与患者、牙科和治疗以及镇静变量相关的数据,并在一周后完成家长的术后电话评估。

结果

发现使用该技术成功完成了96%所需的牙科治疗,93%的家长认为该技术可接受。50%的儿童认为鼻内给予咪达唑仑可接受。手术过程中未出现临床相关的氧饱和度降低。患者血流动力学稳定,整个手术过程中保持了言语交流。

结论

在选定的病例中,该技术为DGA提供了一种安全有效的替代方法,并可减少转诊至医院进行DGA的患者数量。建议该技术仅应由熟练掌握镇静技术且有合适人员和设备可供使用的牙医使用。

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