University of California Irvine Medical Center, Irvine, USA.
Int J Audiol. 2010 Feb;49(2):129-40. doi: 10.3109/14992020903289790.
Efforts to correlate peripheral neurophysiologic function with perceptional deficits seen in autistic disorder (AD) have resulted in mixed findings, reflecting the high degree of heterogeneity observed in these individuals. We used the auditory brainstem response to study the effect of stress (high click presentation rate) on the auditory system in 20 children with AD (7-13 years) and 20 age-matched typically developing (TD) children. We report latency prolongations in children with AD vs. TD at waves I, III, and V that differed by ear of presentation: overall, left ear showed significant prolongations by group while right ear did not. The 'stressed' condition produced prolongations for both groups at each wave. At wave V, children with AD showed significant prolongations vs. TD, particularly for the right ear. For children with AD, wave V latency prolongations corresponded to language outcome as measured by VIQ, with longer prolongations associating with lower VIQ. Preliminary results provide evidence for reduced synaptic efficiency in auditory pathways in children with AD, which may form the neural bases for sensory reactivity and language impairment.
努力将外周神经生理功能与自闭症障碍（AD）中观察到的感知缺陷相关联，得出的结果喜忧参半，反映了这些个体中观察到的高度异质性。我们使用听觉脑干反应来研究应激（高点击呈现率）对 20 名 AD（7-13 岁）儿童和 20 名年龄匹配的正常发育（TD）儿童听觉系统的影响。我们报告了 AD 组与 TD 组在 I、III 和 V 波的潜伏期延长，其表现为耳呈现的差异：总体而言，左耳表现出显著的组间延长，而右耳则没有。在每个波中，“应激”状态都会使两组的潜伏期延长。在 V 波中，AD 患儿与 TD 相比，潜伏期延长明显，尤其是右耳。对于 AD 患儿，V 波潜伏期延长与言语智商（VIQ）测量的语言结果相对应，潜伏期延长与 VIQ 降低相关。初步结果为 AD 患儿听觉通路中的突触效率降低提供了证据，这可能是感觉反应性和语言障碍的神经基础。
