Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Neuron. 2010 Jan 14;65(1):3-4. doi: 10.1016/j.neuron.2009.12.030.
Only doubling or tripling alpha-synuclein expression significantly increases the risk of developing Parkinson's disease. In this issue of Neuron, Nemani et al. show that this modest overexpression of alpha-synuclein does not lead to obvious toxicity in the near term, but impairs glutamate and dopamine release, potentially leading to broad network dysfunction and eventual pathology.
只有将 α-突触核蛋白的表达水平提高两倍或三倍，才会显著增加帕金森病的发病风险。在本期《神经元》杂志中，Nemani 等人表明，这种适度的 α-突触核蛋白过表达在短期内并不会导致明显的毒性，但会损害谷氨酸和多巴胺的释放，可能导致广泛的网络功能障碍和最终的病理变化。
