UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK.
Dev Cell. 2010 Jan 19;18(1):1-2. doi: 10.1016/j.devcel.2010.01.002.
Mammalian neurulation is completed when the dorsolateral neural folds bend inwards, their tips make adhesive contacts across the midline, and the epithelia remodel to create a closed neural tube. Two recent papers (one by Camerer et al. in this issue of Developmental Cell) demonstrate a vital role for protease-activated G protein-coupled receptor signaling in these late closure events, opening up new avenues for exploring the molecular basis of mammalian neural tube morphogenesis.
哺乳动物的神经胚形成过程完成于背外侧神经褶向内弯曲时，其顶端在中线处发生黏附接触，上皮细胞重塑以形成封闭的神经管。最近的两篇论文（其中一篇由 Camerer 等人在本期《发育细胞》中发表）证明了蛋白酶激活的 G 蛋白偶联受体信号在这些晚期闭合事件中的重要作用，为探索哺乳动物神经管形态发生的分子基础开辟了新的途径。
