Humboldt-Universität zu Berlin, Germany.
Biol Psychol. 2010 May;84(2):257-63. doi: 10.1016/j.biopsycho.2010.02.002. Epub 2010 Feb 10.
Performance monitoring has been consistently found to be overactive in obsessive-compulsive disorder (OCD). The present study examines whether performance monitoring in OCD is adjusted with error significance. Therefore, errors in a flanker task were followed by neutral (standard condition) or punishment feedbacks (punishment condition). In the standard condition patients had significantly larger error-related negativity (ERN) and correct-related negativity (CRN) ampliudes than controls. But, in the punishment condition groups did not differ in ERN and CRN amplitudes. While healthy controls showed an amplitude enhancement between standard and punishment condition, OCD patients showed no variation. In contrast, group differences were not found for the error positivity (Pe): both groups had larger Pe amplitudes in the punishment condition. Results confirm earlier findings of overactive error monitoring in OCD. The absence of a variation with error significance might indicate that OCD patients are unable to down-regulate their monitoring activity according to external requirements.
表现监测在强迫症（OCD）中一直被发现过度活跃。本研究检验了 OCD 中的表现监测是否可以根据错误的重要性进行调整。因此，在侧抑制任务中，错误后面跟着中性（标准条件）或惩罚反馈（惩罚条件）。在标准条件下，患者的错误相关负波（ERN）和正确相关负波（CRN）振幅明显大于对照组。但是，在惩罚条件下，两组在 ERN 和 CRN 振幅上没有差异。而健康对照组在标准和惩罚条件之间表现出振幅增强，而 OCD 患者则没有变化。相反，对于错误正波（Pe），两组在惩罚条件下的振幅都较大，没有组间差异。结果证实了 OCD 中表现监测过度活跃的早期发现。缺乏根据错误重要性的变化可能表明 OCD 患者无法根据外部要求调节其监测活动。
