Visa Laura, Caballero Miguel, Grau Juan J
Servicio Oncología, Universidad de Barcelona, Hospital Clínic, IDIBAPS, Barcelona, España.
Acta Otorrinolaringol Esp. 2010 Nov-Dec;61(6):452-4. doi: 10.1016/j.otorri.2009.10.008. Epub 2010 Feb 11.
Formerly, salivary gland cancer was considered to be chemoresistant. Chemotherapy is indicated when distant metastases or inoperable locorregional disease are observed, although the chemotherapy schedule is not well defined. Data on chemotherapy treatment for adenoid cystic carcinoma consist of phase II trials. Most of these studies analyze therapies with a combination of agents at full dose, although there is no clear evidence that such treatment improves survival. The administration of cytotoxic agents with low doses at frequent, regular intervals with no drug-free interruptions is known as metronomic chemotherapy. Most head-to-head studies show similar or even superior therapeutic results with metronomic scheduling than with a maximum tolerated dose regime. Our case report shows for first time the clinical activity of low-dose paclitaxel and cisplatin chemotherapy given separately as a single agent in metastatic adenoid cystic carcinoma of the parotid.
以前，唾液腺癌被认为对化疗耐药。当观察到远处转移或局部区域疾病无法手术时，需进行化疗，不过化疗方案尚未明确界定。关于腺样囊性癌化疗治疗的数据来自II期试验。这些研究大多分析了全剂量联合用药的疗法，尽管尚无明确证据表明这种治疗能提高生存率。以低剂量、频繁且规律的间隔给药，且无药物中断期，这种给药方式被称为节拍化疗。大多数头对头研究表明，与最大耐受剂量方案相比，节拍化疗方案的治疗效果相似甚至更优。我们的病例报告首次展示了低剂量紫杉醇和顺铂作为单药分别用于腮腺转移性腺样囊性癌化疗时的临床活性。
