Department of Reproductive Endocrinology, Zekai Tahir Burak Women's Health Research and Education Hospital, Ankara, Turkey.
Int J Gynaecol Obstet. 2010 Jun;109(3):226-9. doi: 10.1016/j.ijgo.2009.12.015. Epub 2010 Feb 11.
To investigate the effects on adhesion formation and pregnancy maintenance of an intrauterine device (IUD) and/or estrogen treatment after hysteroscopic septum resection.
After septum resection 100 women received either no treatment, or estrogens, or an IUD, or an IUD plus estrogens (n=25 per group). Most were later checked hysteroscopically for uterine cavity adhesions. All pregnancies occurring during the study period were recorded.
Adhesions developed in 1 of 19 (5.3%) of the untreated women, 3 of 25 (12%) of the women treated with an IUD plus estrogens, 2 of 19 (10.5%) of the women treated with an IUD only, and none of the women treated with estrogens only. None of the differences, however, were significant. Regarding pregnancy, the differences between groups were also not significant.
Neither IUD placement, nor estrogen treatment, nor both were found to prevent intrauterine adhesions or facilitate pregnancy after hysteroscopic uterine septum resection.
研究宫腔镜子宫中隔切除术(hysteroscopic septum resection)后放置宫内节育器(IUD)和/或雌激素治疗对粘连形成和妊娠维持的影响。
子宫中隔切除术后,100 名女性被分为四组,分别为未治疗组、雌激素治疗组、IUD 治疗组和 IUD 加雌激素治疗组(每组 25 人)。大多数患者随后接受宫腔镜检查以评估宫腔粘连情况。研究期间发生的所有妊娠均被记录。
未治疗组中有 1 例(5.3%)出现粘连,IUD 加雌激素治疗组中有 3 例(12%),IUD 治疗组中有 2 例(10.5%),雌激素治疗组中无一例发生粘连。但这些差异均无统计学意义。至于妊娠,各组之间的差异也无统计学意义。
宫腔镜子宫中隔切除术后,放置 IUD、雌激素治疗或两者联合应用均不能预防宫腔粘连或促进妊娠。