Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Schizophr Res. 2010 May;118(1-3):113-7. doi: 10.1016/j.schres.2010.01.014. Epub 2010 Feb 11.
The aim of the current study was to examine the association of KREMEN1 and DKK1, two wnt pathway-related genes with schizophrenia in Japanese subjects. We genotyped 16 common genetic variants within the aforementioned genes and examined their associations with schizophrenia. Results demonstrated that a common variant in the promoter region of KREMEN1 might modulate the risk of schizophrenia in the Japanese. However, further replication will be needed for conclusive interpretation of the effect of this locus on the pathogenesis of schizophrenia.
本研究旨在探讨与精神分裂症相关的 Wnt 通路相关基因 KREMEN1 和 DKK1 与日本人群精神分裂症的关联。我们对上述基因内的 16 个常见遗传变异进行了基因分型，并检测了它们与精神分裂症的关联。结果表明，KREMEN1 启动子区域的常见变异可能调节日本人群精神分裂症的发病风险。然而，需要进一步的复制来确定该基因座对精神分裂症发病机制的影响。
