Department of Psychiatry, College of Medicine, Kaohsiung Medical University and Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
Psychiatry Res. 2010 Mar 30;181(3):199-203. doi: 10.1016/j.pscychresns.2009.10.001. Epub 2010 Feb 11.
In this study, short echo time (1)H-magnetic resonance spectroscopy (MRS) was applied for quantification of neurometabolites using the LC Model algorithm in Taiwanese adolescents with attention-deficit hyperactivity disorder (ADHD). Proton magnetic resonance spectra were acquired bilaterally on the prefrontal area (part of the anterior cingulate gyrus and part of the medial frontal gyrus) in 15 adolescents with ADHD (average age of 13.88years) and 22 controls (average age of 14.85years). Absolute metabolite levels and ratios relative to creatine plus phosphocreatine (Cr+PCr) were obtained to be compared between groups. Results showed that adolescents with ADHD had significantly lower mean right prefrontal levels of Cr+PCr as compared with the controls. No significant differences between groups were noted in the remainder of the prefrontal metabolites. As for the group comparison of relative ratios, the N-acetylaspartate/Cr+PCr ratio was significantly higher in the right prefrontal regions of ADHD adolescents. This finding provides evidence of a right prefrontal neurochemical alteration in ADHD adolescents, which is consistent with current ADHD theory of prefrontal neuropathology with developmental mechanism. In addition, it highlights the importance of the method in interpretation of MRS findings in the context of ADHD.
在这项研究中，应用短回波时间 (1)H 磁共振波谱（MRS）结合 LCModel 算法对台湾地区注意缺陷多动障碍（ADHD）青少年进行神经代谢物定量分析。15 名 ADHD 青少年（平均年龄 13.88 岁）和 22 名对照组（平均年龄 14.85 岁）双侧前额区（前扣带回和内侧额回的一部分）采集质子磁共振波谱。获得与肌酸加磷酸肌酸（Cr+PCr）的绝对代谢物水平和比值，并在组间进行比较。结果显示，与对照组相比，ADHD 青少年右侧前额区 Cr+PCr 的平均水平明显较低。前额叶其余代谢物在两组间无显著差异。对于相对比值的组间比较，ADHD 青少年右侧前额区的 N-乙酰天门冬氨酸/Cr+PCr 比值显著升高。这一发现为 ADHD 青少年前额叶神经化学改变提供了证据，与当前 ADHD 前额叶神经病理学的发展机制理论一致。此外，它强调了该方法在 ADHD 背景下解释 MRS 结果的重要性。
