Debnam E S, Srai S K, Chowrimootoo G, Epstein O
Department of Physiology, Royal Free Hospital School of Medicine, London, UK.
Biol Neonate. 1991;59(1):30-6. doi: 10.1159/000243319.
Although the neonatal guinea pig has substantial body iron stores, the rate of duodenal iron absorption is greater than in the mature animal. Here we have used brush border membrane vesicles and biopsy tissue to examine the role of the brush border in changes in Fe2+ and Fe3+ uptake by the duodenum of newborn and adult guinea pigs. We conclude that the brush border membrane is unlikely to be an important site for developmental alterations in iron absorption. Autoradiographic analysis of Fe2+ uptake, however, implies that whilst only the upper villus cells of adult duodenal villi are involved in iron uptake, all enterocytes in the neonate display this function.
尽管新生豚鼠体内有大量的机体铁储备，但十二指肠铁吸收速率高于成年动物。在此，我们使用刷状缘膜囊泡和活检组织来研究刷状缘在新生和成年豚鼠十二指肠对Fe2+和Fe3+摄取变化中的作用。我们得出结论，刷状缘膜不太可能是铁吸收发育改变的重要部位。然而，对Fe2+摄取的放射自显影分析表明，虽然成年十二指肠绒毛只有上部绒毛细胞参与铁摄取，但新生豚鼠的所有肠上皮细胞都具有这种功能。
