Nieto Guevara J, Luciani K, Montesdeoca Melián A, Mateos Durán M, Estripeaut D
Instituto Conmemorativo Gorgas de Estudios de la Salud, Panamá, Panamá.
An Pediatr (Barc). 2010 Mar;72(3):172-8. doi: 10.1016/j.anpedi.2009.11.012. Epub 2010 Feb 12.
Bordetella pertussis (whooping cough) is a worldwide public health problem. It is estimated that there are about 20 to 40 million cases with 200,000-400,000 deaths and is increasing in infants and adults.
An observational, retrospective study was made. We reviewed the epidemiologic surveillance notification forms from 2001 to 2008 period at the Epidemiology Department of Hospital Del Niño, a tertiary paediatric reference centre in Panama City. All pertussis (whooping cough) cases confirmed by PCR and cultures were selected.
From a total of 759 notifications of suspected whooping cough cases, 180 confirmed cases using PCR and culture were analyzed for this study. The admission rate in all ages was 14.4/10,000 admissions, predominantly in < or =3 months with 42.76/10,000 admissions and which accounted for 75% of the cases. Cough was the most important symptom (91%). Cyanosis, leucocytosis and lymphocytosis were the most characteristic clinical findings when comparing positive pertussis with negative. More than two thirds of the subjects less than 3 months of age had not been vaccinated at the time of admission. The death rate was 8.3%, more than half of them in subjects less than 1 month of age.
Whooping cough is an important public health problem. Post-partum vaccination could be a strategy to reduce morbidity and mortality in infants less than 3 months of age.
百日咳博德特氏菌（百日咳）是一个全球性的公共卫生问题。据估计，全球约有2000万至4000万病例，20万至40万人死亡，且在婴儿和成人中的发病率呈上升趋势。
进行了一项观察性回顾性研究。我们查阅了巴拿马城一家三级儿科参考中心——儿童医院流行病学部2001年至2008年期间的流行病学监测报告表。选取了所有经聚合酶链反应（PCR）和培养确诊的百日咳病例。
在总共759例疑似百日咳病例报告中，本研究分析了180例经PCR和培养确诊的病例。各年龄段的入院率为14.4/10000例入院患者，主要是年龄小于或等于3个月的婴儿，入院率为42.76/10000例入院患者，占病例总数的75%。咳嗽是最重要的症状（91%）。与百日咳阴性病例相比，发绀、白细胞增多和淋巴细胞增多是百日咳阳性病例最具特征性的临床表现。超过三分之二的3个月以下婴儿在入院时未接种疫苗。死亡率为8.3%，其中一半以上为1个月以下的婴儿。
百日咳是一个重要的公共卫生问题。产后接种疫苗可能是降低3个月以下婴儿发病率和死亡率的一种策略。
