Department of Psychology, Fo Guang University, Yilan County 26247, Taiwan.
Pharmacol Biochem Behav. 2010 May;95(3):285-91. doi: 10.1016/j.pbb.2010.02.003. Epub 2010 Feb 11.
We studied whether a cascade of different phases of ingestive behavior were governed by different doses of the dopamine D2 receptor system. A wide spectrum of doses (0, 0.025, 0.05, 0.1, 0.2, and 0.4mg/kg) of a D2 receptor antagonist, haloperidol, were administered to 6 groups of water-deprived rats. 45min following administration of the drug a 15min water intake session was allowed to assess the effect on (a) locomotion, (b) appetitive response and (c) consummatory responses. The procedure was repeated for 5days.
The doses of 0.025 to 0.1mg/kg had no effects on any measured behavior compared with the control group. The 0.2mg/kg dose induced catalepsy during sessions 3 and 5 and impaired consummatory (decreased lick numbers and intake volume) behaviors during sessions 1-5. The 0.4mg/kg dose affected appetitive behavior (increased latency to contact the water tube) during session 2 and consummatory behavior during all five water sessions. The 0.2mg/kg dose appeared to dissociate appetitive and consummatory behavior, and the 0.4mg/kg dose locomotor activity and motivational behavior (including consummatory and appetitive responses). These results, that the three elements of ingestive behavior (locomotion, appetitive responses, and consummatory behavior) have different sensitivity to haloperidol, suggest that separable D2 mechanisms are involved in governing the ingestive behavior.
我们研究了不同剂量的多巴胺 D2 受体系统是否控制了不同阶段的摄食行为。给 6 组缺水的大鼠注射了广泛剂量范围（0、0.025、0.05、0.1、0.2 和 0.4mg/kg）的 D2 受体拮抗剂氟哌啶醇。在药物给药后 45 分钟，允许进行 15 分钟的水摄入测试，以评估其对（a）运动、（b）食欲反应和（c）摄取反应的影响。该程序重复进行了 5 天。
与对照组相比，0.025 至 0.1mg/kg 的剂量对任何测量的行为均无影响。0.2mg/kg 的剂量在第 3 天和第 5 天引起了僵住，并在第 1 天至第 5 天期间损害了摄取行为（减少舔的次数和摄入量）。0.4mg/kg 的剂量在第 2 天影响了食欲行为（接触水喉的潜伏期延长），在所有 5 个水测试期间影响了摄取行为。0.2mg/kg 的剂量似乎使食欲和摄取行为分离，0.4mg/kg 的剂量使运动活动和动机行为（包括摄取和食欲反应）分离。这些结果表明，摄食行为的三个要素（运动、食欲反应和摄取行为）对氟哌啶醇的敏感性不同，表明参与摄食行为调节的是可分离的 D2 机制。
