Simmen F A, Simmen R C
Dairy Science Department, University of Florida, Gainesville 32611-0701.
Biol Reprod. 1991 Jan;44(1):1-5. doi: 10.1095/biolreprod44.1.1.
Development of mammalian conceptuses (embryo and associated membranes) in utero is an extremely complex, programmed orchestration of cellular activities that include proliferation, differentiation, migration, and death. Failure of conceptuses to develop is a significant, though not well-understood, problem in human and animal reproduction. Increased understanding of molecular and cellular processes in these events is ultimately required to determine the mechanisms responsible for developmental failures. Peptide growth factors, their associated proteins (carrier proteins and membrane receptors), and proto-oncogenes (the normal, cellular counterparts of retroviral oncogenic proteins) are intimately involved in normal and abnormal cellular growth regulation. This paper highlights recent work which suggests the involvement of these proteins in critical aspects of conceptus growth and uterine-conceptus interactions during the peri-implantation period.
哺乳动物胚胎（胚胎及其相关膜）在子宫内的发育是一个极其复杂的、程序化的细胞活动编排，这些活动包括增殖、分化、迁移和死亡。胚胎发育失败是人类和动物生殖中一个重大但尚未完全理解的问题。最终需要更多地了解这些事件中的分子和细胞过程，以确定导致发育失败的机制。肽生长因子、其相关蛋白（载体蛋白和膜受体）以及原癌基因（逆转录病毒致癌蛋白的正常细胞对应物）密切参与正常和异常的细胞生长调节。本文重点介绍了最近的研究工作，这些工作表明这些蛋白在着床前期胚胎生长和子宫 - 胚胎相互作用的关键方面发挥作用。
