旧变体的新功能：组蛋白 H3.3 无可替代。
New functions for an old variant: no substitute for histone H3.3.
机构信息
The Rockefeller University, New York, NY 10065, USA.
出版信息
Curr Opin Genet Dev. 2010 Apr;20(2):110-7. doi: 10.1016/j.gde.2010.01.003. Epub 2010 Feb 12.
Abstract
Histone proteins often come in different variants serving specialized functions in addition to their fundamental role in packaging DNA. The metazoan histone H3.3 has been most closely associated with active transcription. Its role in histone replacement at active genes and promoters is conserved to the single histone H3 in yeast. However, recent genetic studies in flies have challenged its importance as a mark of active chromatin, and revealed unexpected insights into essential functions of H3.3 in the germline. With strikingly little amino acid sequence difference to the canonical H3, H3.3 therefore accomplishes a surprising variety of cellular and developmental processes.
摘要
组蛋白蛋白通常有不同的变体，除了在包装 DNA 方面的基本作用外，还具有专门的功能。后生动物组蛋白 H3.3 与活跃的转录最为密切相关。其在活性基因和启动子处组蛋白替换中的作用在酵母中单一的组蛋白 H3 中是保守的。然而，最近在果蝇中的遗传研究对其作为活性染色质标记的重要性提出了挑战，并揭示了 H3.3 在生殖细胞中意想不到的重要功能。由于与典型的 H3 只有很少的氨基酸序列差异，因此 H3.3 完成了惊人的各种细胞和发育过程。
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1
Distinct factors control histone variant H3.3 localization at specific genomic regions.
Cell. 2010 Mar 5;140(5):678-91. doi: 10.1016/j.cell.2010.01.003.
2
H2A.Z and H3.3 histone variants affect nucleosome structure: biochemical and biophysical studies.
Biochemistry. 2009 Nov 24;48(46):10852-7. doi: 10.1021/bi901129e.
3
Histone H1 binding is inhibited by histone variant H3.3.
EMBO J. 2009 Dec 2;28(23):3635-45. doi: 10.1038/emboj.2009.301. Epub 2009 Oct 15.
4
Transcriptional and developmental functions of the H3.3 histone variant in Drosophila.
Curr Biol. 2009 Nov 17;19(21):1816-20. doi: 10.1016/j.cub.2009.09.021. Epub 2009 Sep 24.
5
Histone chaperone spt16 promotes redeposition of the original h3-h4 histones evicted by elongating RNA polymerase.
Mol Cell. 2009 Aug 14;35(3):377-83. doi: 10.1016/j.molcel.2009.07.001.
6
Two-color cell array screen reveals interdependent roles for histone chaperones and a chromatin boundary regulator in histone gene repression.
Mol Cell. 2009 Aug 14;35(3):340-51. doi: 10.1016/j.molcel.2009.06.023.
7
Chromatin: sub out the replacement.
Curr Biol. 2009 Jul 28;19(14):R545-7. doi: 10.1016/j.cub.2009.06.032.
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H3.3/H2A.Z double variant-containing nucleosomes mark 'nucleosome-free regions' of active promoters and other regulatory regions.
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9
The fission yeast HIRA histone chaperone is required for promoter silencing and the suppression of cryptic antisense transcripts.
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10
A unifying model for the selective regulation of inducible transcription by CpG islands and nucleosome remodeling.
Cell. 2009 Jul 10;138(1):114-28. doi: 10.1016/j.cell.2009.04.020.
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