旧变体的新功能：组蛋白 H3.3 无可替代。
New functions for an old variant: no substitute for histone H3.3.
机构信息
The Rockefeller University, New York, NY 10065, USA.
出版信息
Curr Opin Genet Dev. 2010 Apr;20(2):110-7. doi: 10.1016/j.gde.2010.01.003. Epub 2010 Feb 12.
Abstract
Histone proteins often come in different variants serving specialized functions in addition to their fundamental role in packaging DNA. The metazoan histone H3.3 has been most closely associated with active transcription. Its role in histone replacement at active genes and promoters is conserved to the single histone H3 in yeast. However, recent genetic studies in flies have challenged its importance as a mark of active chromatin, and revealed unexpected insights into essential functions of H3.3 in the germline. With strikingly little amino acid sequence difference to the canonical H3, H3.3 therefore accomplishes a surprising variety of cellular and developmental processes.
摘要
组蛋白蛋白通常有不同的变体，除了在包装 DNA 方面的基本作用外，还具有专门的功能。后生动物组蛋白 H3.3 与活跃的转录最为密切相关。其在活性基因和启动子处组蛋白替换中的作用在酵母中单一的组蛋白 H3 中是保守的。然而，最近在果蝇中的遗传研究对其作为活性染色质标记的重要性提出了挑战，并揭示了 H3.3 在生殖细胞中意想不到的重要功能。由于与典型的 H3 只有很少的氨基酸序列差异，因此 H3.3 完成了惊人的各种细胞和发育过程。
相似文献
1
New functions for an old variant: no substitute for histone H3.3.旧变体的新功能：组蛋白 H3.3 无可替代。
Curr Opin Genet Dev. 2010 Apr;20(2):110-7. doi: 10.1016/j.gde.2010.01.003. Epub 2010 Feb 12.
2
Epigenetic and replacement roles of histone variant H3.3 in reproduction and development.组蛋白变体H3.3在生殖与发育中的表观遗传及替代作用。
Int J Dev Biol. 2009;53(2-3):231-43. doi: 10.1387/ijdb.082653go.
3
Transcriptional and developmental functions of the H3.3 histone variant in Drosophila.果蝇中 H3.3 组蛋白变体的转录和发育功能。
Curr Biol. 2009 Nov 17;19(21):1816-20. doi: 10.1016/j.cub.2009.09.021. Epub 2009 Sep 24.
4
The Ino80 complex mediates epigenetic centromere propagation via active removal of histone H3.INO80 复合物通过活性去除组蛋白 H3 介导表观遗传着丝粒传播。
Nat Commun. 2017 Sep 13;8(1):529. doi: 10.1038/s41467-017-00704-3.
5
The double face of the histone variant H3.3.组蛋白变体 H3.3 的双重面孔。
Cell Res. 2011 Mar;21(3):421-34. doi: 10.1038/cr.2011.14. Epub 2011 Jan 25.
6
Continuous histone H2B and transcription-dependent histone H3 exchange in yeast cells outside of replication.酵母细胞中复制以外区域的组蛋白H2B持续交换和转录依赖性组蛋白H3交换
Mol Cell. 2007 Feb 9;25(3):345-55. doi: 10.1016/j.molcel.2007.01.019.
7
Histone H3.3 variant dynamics in the germline of Caenorhabditis elegans.秀丽隐杆线虫生殖系中组蛋白H3.3变体的动态变化
PLoS Genet. 2006 Jun;2(6):e97. doi: 10.1371/journal.pgen.0020097.
8
Dynamic replacement of histone H3 variants reprograms epigenetic marks in early mouse embryos.组蛋白 H3 变体的动态替换重新编程了早期小鼠胚胎中的表观遗传标记。
PLoS Genet. 2011 Oct;7(10):e1002279. doi: 10.1371/journal.pgen.1002279. Epub 2011 Oct 6.
9
The evolutionary history of histone H3 suggests a deep eukaryotic root of chromatin modifying mechanisms.组蛋白 H3 的进化历史表明染色质修饰机制具有深层真核生物根源。
BMC Evol Biol. 2010 Aug 25;10:259. doi: 10.1186/1471-2148-10-259.
10
Genome editing a mouse locus encoding a variant histone, H3.3B, to report on its expression in live animals.对编码变体组蛋白H3.3B的小鼠基因座进行基因组编辑，以报告其在活体动物中的表达情况。
Genesis. 2014 Dec;52(12):959-66. doi: 10.1002/dvg.22827. Epub 2014 Oct 6.
引用本文的文献
1
Creation of true interspecies hybrids: Rescue of hybrid class with hybrid cytoplasm affecting growth and metabolism.真正的种间杂种的创造：拯救具有影响生长和代谢的杂种细胞质的杂种类。
Sci Adv. 2024 Oct 25;10(43):eadq4339. doi: 10.1126/sciadv.adq4339. Epub 2024 Oct 23.
2
Multifunctional histone variants in genome function.基因组功能中的多功能组蛋白变体
Nat Rev Genet. 2025 Feb;26(2):82-104. doi: 10.1038/s41576-024-00759-1. Epub 2024 Aug 13.
3
Haspin mediates H3.3S31 phosphorylation downstream of Aurora B in mouse embryonic stem cells.组蛋白 H3.3 的丝氨酸 31 磷酸化由 Aurora B 激酶在小鼠胚胎干细胞中调控。
Protein Sci. 2024 Aug;33(8):e5126. doi: 10.1002/pro.5126.
4
Lysine-36 of Drosophila histone H3.3 supports adult longevity.果蝇组蛋白 H3.3 的赖氨酸 36 支持成虫寿命。
G3 (Bethesda). 2024 Apr 3;14(4). doi: 10.1093/g3journal/jkae030.
5
Lysine-36 of histone H3.3 supports adult longevity.组蛋白H3.3的赖氨酸-36支持成年期长寿。
bioRxiv. 2023 Dec 13:2023.09.28.559962. doi: 10.1101/2023.09.28.559962.
6
Histone Variants and Their Chaperones in Hematological Malignancies.血液系统恶性肿瘤中的组蛋白变体及其伴侣蛋白
Hemasphere. 2023 Jul 11;7(8):e927. doi: 10.1097/HS9.0000000000000927. eCollection 2023 Aug.
7
Involvement of the H3.3 Histone Variant in the Epigenetic Regulation of Gene Expression in the Nervous System, in Both Physiological and Pathological Conditions.组蛋白 H3.3 变体在神经系统中基因表达的表观遗传调控中的作用，无论是在生理还是病理条件下。
Int J Mol Sci. 2023 Jul 3;24(13):11028. doi: 10.3390/ijms241311028.
8
Distinct roles for canonical and variant histone H3 lysine-36 in Polycomb silencing.组蛋白 H3 赖氨酸-36 的经典和变体在 Polycomb 沉默中的不同作用。
Sci Adv. 2023 Mar;9(9):eadf2451. doi: 10.1126/sciadv.adf2451. Epub 2023 Mar 1.
9
A knockout-first model of H3f3a gene targeting leads to developmental lethality.H3f3a 基因靶向的敲除优先模型导致发育致死。
Genesis. 2023 Mar;61(1-2):e23507. doi: 10.1002/dvg.23507. Epub 2023 Jan 19.
10
Characterization of Histone H3 Gene Family Reveals That is Associated With Higher Seed Weight in .组蛋白H3基因家族的特征分析表明，[具体内容缺失]与[具体物种缺失]中较高的种子重量相关。
Front Genet. 2022 Jul 22;13:949027. doi: 10.3389/fgene.2022.949027. eCollection 2022.
本文引用的文献
1
Distinct factors control histone variant H3.3 localization at specific genomic regions.不同的因素控制着组蛋白变体 H3.3 在特定基因组区域的定位。
Cell. 2010 Mar 5;140(5):678-91. doi: 10.1016/j.cell.2010.01.003.
2
H2A.Z and H3.3 histone variants affect nucleosome structure: biochemical and biophysical studies.H2A.Z和H3.3组蛋白变体影响核小体结构：生化与生物物理研究
Biochemistry. 2009 Nov 24;48(46):10852-7. doi: 10.1021/bi901129e.
3
Histone H1 binding is inhibited by histone variant H3.3.组蛋白 H1 的结合受到组蛋白变体 H3.3 的抑制。
EMBO J. 2009 Dec 2;28(23):3635-45. doi: 10.1038/emboj.2009.301. Epub 2009 Oct 15.
4
Transcriptional and developmental functions of the H3.3 histone variant in Drosophila.果蝇中 H3.3 组蛋白变体的转录和发育功能。
Curr Biol. 2009 Nov 17;19(21):1816-20. doi: 10.1016/j.cub.2009.09.021. Epub 2009 Sep 24.
5
Histone chaperone spt16 promotes redeposition of the original h3-h4 histones evicted by elongating RNA polymerase.组蛋白伴侣spt16促进被延伸的RNA聚合酶驱逐的原始H3-H4组蛋白的重新沉积。
Mol Cell. 2009 Aug 14;35(3):377-83. doi: 10.1016/j.molcel.2009.07.001.
6
Two-color cell array screen reveals interdependent roles for histone chaperones and a chromatin boundary regulator in histone gene repression.双色细胞阵列筛选揭示了组蛋白伴侣和染色质边界调节因子在组蛋白基因抑制中的相互依赖作用。
Mol Cell. 2009 Aug 14;35(3):340-51. doi: 10.1016/j.molcel.2009.06.023.
7
Chromatin: sub out the replacement.染色质：更换替代物。
Curr Biol. 2009 Jul 28;19(14):R545-7. doi: 10.1016/j.cub.2009.06.032.
8
H3.3/H2A.Z double variant-containing nucleosomes mark 'nucleosome-free regions' of active promoters and other regulatory regions.含有H3.3/H2A.Z双变体的核小体标记活跃启动子和其他调控区域的“无核小体区域”。
Nat Genet. 2009 Aug;41(8):941-5. doi: 10.1038/ng.409. Epub 2009 Jul 26.
9
The fission yeast HIRA histone chaperone is required for promoter silencing and the suppression of cryptic antisense transcripts.裂殖酵母HIRA组蛋白伴侣对于启动子沉默和隐蔽反义转录本的抑制是必需的。
Mol Cell Biol. 2009 Sep;29(18):5158-67. doi: 10.1128/MCB.00698-09. Epub 2009 Jul 20.
10
A unifying model for the selective regulation of inducible transcription by CpG islands and nucleosome remodeling.一种关于CpG岛和核小体重塑对诱导性转录进行选择性调控的统一模型。
Cell. 2009 Jul 10;138(1):114-28. doi: 10.1016/j.cell.2009.04.020.
Zotero 插件