在临床稳定的 CF 患者中，血小板的促炎活性始于幼儿期。
Platelet proinflammatory activity in clinically stable patients with CF starts in early childhood.
机构信息
University Children's Hospital, 97080 Würzburg, Germany.
出版信息
J Cyst Fibros. 2010 May;9(3):179-86. doi: 10.1016/j.jcf.2009.12.004. Epub 2010 Feb 12.
BACKGROUND
Early onset chronic inflammation is present in CF. Platelets may contribute to inflammation by cytokine release and interaction with leukocytes.
METHODS
Parameters of platelet proinflammatory function (soluble CD62P, soluble CD40L, the percentage of platelet-leukocyte aggregates, platelet CD62P) and platelet procoagulatory function (PAC-1-binding to activated integrin alpha(IIb)beta(3) and expression of integrin alpha(IIb)beta(3)=CD41a) were measured in patients and controls.
RESULTS
Levels of sCD62P, sCD40L were increased in CF irrespective of age and activity of inflammation. The number of platelet-leukocyte aggregates was elevated in older CF patients. PAC-1-binding to platelets decreased with growing activity of inflammation. Exocytosis of CD41a upon platelet activation was reduced.
CONCLUSION
In CF, platelet proinflammatory activity is increased at very young age already and might promote inflammation and tissue damage. On the other hand, platelets seem to downregulate the activation of their most important integrin (alpha(IIb)beta(3)) for clot formation.
背景
CF 中存在早期发病的慢性炎症。血小板通过细胞因子释放和与白细胞相互作用可能导致炎症。
方法
在患者和对照组中测量血小板促炎功能（可溶性 CD62P、可溶性 CD40L、血小板-白细胞聚集体的百分比、血小板 CD62P）和血小板促凝功能（PAC-1 与激活的整合素 α(IIb)β(3)结合和整合素 α(IIb)β(3)=CD41a 的表达）的参数。
结果
CF 患者无论炎症的活动度和年龄如何，sCD62P 和 sCD40L 的水平均升高。老年 CF 患者的血小板-白细胞聚集体数量增加。随着炎症活动度的增加，PAC-1 与血小板的结合减少。血小板活化时 CD41a 的胞吐作用减少。
结论
在 CF 中，血小板的促炎活性在非常年轻的时候就已经增加，可能会促进炎症和组织损伤。另一方面，血小板似乎下调了其最重要的整合素（α(IIb)β(3)）的激活，以形成血栓。
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