Department of Psychiatry and Institute of Behavioral Science in Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.
Neuropharmacology. 2010 Jun;58(7):1109-13. doi: 10.1016/j.neuropharm.2010.02.001. Epub 2010 Feb 12.
Decision making is an important brain function. Although little is known about the genetic basis of decision making, it has been suggested that it is mediated by the modulation of neurotransmitter systems. We investigated how the BDNF Val66Met and COMT Val158Met polymorphisms affect emotional decision making using the Iowa Gambling Task (IGT). One hundred sixty-eight healthy Korean college students (93 males, 75 females) with a complete dataset were included in the data analysis. The IGT and genotyping for the polymorphisms of BDNF Val66Met and COMT Val158Met were performed. Both Met/Met and Val/Met of the BDNF Val66Met polymorphism were significantly associated with a lower mean score of blocks 3-5 of the IGT and with less improvement from block 1 to block 3-5 than the Val/Val. However, the BDNF was not significantly associated with the score of block 1, and the COMT Val158Met polymorphism produced no significant effect on IGT performance. No interaction effect was observed between the BDNF and the COMT for the IGT. These findings suggest the BDNF Val66Met may affect the emotional decision making performance.
决策是一项重要的大脑功能。尽管人们对决策的遗传基础知之甚少，但有研究表明，它是通过神经递质系统的调节来介导的。我们使用赌博任务（IGT）来研究 BDNF Val66Met 和 COMT Val158Met 多态性如何影响情绪决策。共有 168 名具有完整数据集的健康韩国大学生（男性 93 名，女性 75 名）纳入数据分析。进行了 IGT 和 BDNF Val66Met 和 COMT Val158Met 多态性的基因分型。BDNF Val66Met 多态性的 Met/Met 和 Val/Met 与 IGT 第 3-5 块的平均得分较低显著相关，并且与从第 1 块到第 3-5 块的改善程度低于 Val/Val 显著相关。然而，BDNF 与第 1 块的得分无显著相关性，COMT Val158Met 多态性对 IGT 表现无显著影响。BDNF 和 COMT 之间没有观察到 IGT 的交互作用效应。这些发现表明 BDNF Val66Met 可能影响情绪决策表现。
