Departamento de Bioquímica e Imunologia, Laboratório de Neurociência Comportamental e Molecular, LaNeC, Universidade Federal de Minas Gerais, Belo Horizonte 31270-010, Brazil.
Behav Brain Res. 2010 Jun 26;210(1):140-2. doi: 10.1016/j.bbr.2010.02.019. Epub 2010 Feb 12.
The purposes of the present study were to verify the effects of a severe thiamine deficiency episode on spatial cognitive aspects and thalamic serotonergic parameters. The animals were submitted to a severe thiamine deficiency treatment that was interrupted after the onset of the last neurological signs. The results obtained confirm previous findings about TD deficiency effects on cognitive function and, further show that this vitamin increases the thalamic serotonine metabolite, 5-hidroxyindolacetic acid (5-HIAA), level. In addition, the present data shed light on the importance of this metabolite in spatial cognitive function.
本研究的目的是验证严重硫胺素缺乏症对空间认知方面和丘脑 5-羟色胺能参数的影响。动物在出现最后神经症状后开始接受严重的硫胺素缺乏治疗。结果证实了先前关于 TD 缺乏对认知功能影响的发现，并进一步表明这种维生素增加了丘脑 5-羟吲哚乙酸（5-HIAA）代谢物的水平。此外，本研究数据揭示了这种代谢物在空间认知功能中的重要性。
