Department of Pathophysiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, People's Republic of China.
Cancer Lett. 2010 Jul 28;293(2):167-74. doi: 10.1016/j.canlet.2010.01.006. Epub 2010 Feb 13.
Despite improvements in both surgical techniques and radio- and chemo-therapy regimens, the prognosis of esophageal cancer is poor. In pursuit of novel effective strategy, this study examined the effect of the BH3-mimetic GX15-070 on esophageal carcinoma cells. We discovered that GX15-070 inhibited the growth of esophageal cancer cells. There was synergism between GX15-070 and carboplatin or 5-fluorouracil. GX15-070 induced autophagy in esophagus cancer cell line EC9706 and osteosarcoma cancer cell line U2OS. 3-methyladenine and chloroquine, inhibitors of autophagy with distinct mechanisms, potentiated the cytotoxicity of GX15-070. In conclusion, GX15-070 inhibits growth of esophageal cancer cells.
尽管手术技术和放化疗方案都有所改进，但食管癌的预后仍然很差。为了寻求新的有效策略，本研究探讨了 BH3 模拟物 GX15-070 对食管癌细胞的影响。我们发现 GX15-070 抑制了食管癌的生长。GX15-070 与卡铂或 5-氟尿嘧啶之间存在协同作用。GX15-070 诱导食管癌细胞系 EC9706 和骨肉瘤癌细胞系 U2OS 发生自噬。具有不同机制的自噬抑制剂 3-甲基腺嘌呤和氯喹增强了 GX15-070 的细胞毒性。总之，GX15-070 抑制食管癌的生长。
