Novartis Animal Health Australasia Pty Limited, Clinical Development, Yarrandoo R&D Centre, 245 Western Road, Kemps Creek, NSW 2178, Australia.
Vet Parasitol. 2010 May 11;169(3-4):358-61. doi: 10.1016/j.vetpar.2010.01.012. Epub 2010 Jan 20.
Monepantel is the first molecule from the amino-acetonitrile derivatives to be developed for controlling gastro-intestinal nematodes in sheep. Two studies were undertaken to examine the drug's efficacy against inhibited fourth-stage larvae of Haemonchus contortus and Teladorsagia spp. in sheep when administered as an oral solution at 2.5mg/kg bodyweight. In study 1, efficacy was 99.7% against H. contortus (p<0.0001) and in study 2, 99.8% against Teladorsagia spp. (p<0.0001). This population consisted of 93% T. circumcincta and 7% T. trifurcata. In conclusion, monepantel is a highly effective treatment against inhibited fourth-stage larvae of H. contortus and Teladorsagia spp. and the studies reported here provide the first published evidence of efficacy of this new anthelmintic against these parasites.
苯并咪挫酮是第一个用于控制绵羊胃肠道线虫的氨基乙腈衍生物类药物。进行了两项研究，以检查当以 2.5mg/kg 体重的口服溶液给药时，该药物对受抑制的第四期捻转血矛线虫幼虫和泰乐菌素 spp. 的功效。在研究 1 中，对捻转血矛线虫的功效为 99.7%（p<0.0001），在研究 2 中，对泰乐菌素 spp. 的功效为 99.8%（p<0.0001）。该群体由 93%的泰乐菌素 spp. 和 7%的泰乐菌素 spp. 组成。总之，苯并咪挫酮是一种针对受抑制的第四期捻转血矛线虫幼虫和泰乐菌素 spp. 的高效治疗方法，这里报告的研究提供了这种新驱虫药对这些寄生虫的功效的首次发表证据。
