Agerbaek M O, Eriksen E F, Kragstrup J, Mosekilde L, Melsen F
Aarhus Bone & Mineral Study Group, University Institute of Pathology, Arhus Amtssygehus, Denmark.
Bone Miner. 1991 Feb;12(2):101-12. doi: 10.1016/0169-6009(91)90039-3.
This paper describes the reconstruction of the remodelling cycle in normal iliac crest cortical bone from static and dynamic variables after double labelling with tetracycline in 10 young normal individuals. The average duration of the resorptive period was 27 days during which the average rate of resorption was 4.7 microns/day. The final resorption depth was 76 microns. The diameter of osteoclast containing cutting cones was significantly smaller (P less than 0.05) than cutting cones containing mononuclear cells, indicating an initial osteoclastic resorption phase preceding a mononuclear resorption phase. The average mineralization lag-time was 8 days and the formative period 89 days. Osteoid thickness during this period averaged 5.8 microns. The seam thickness varied with the underlying uncompleted wall thickness, i.e., during the course of the formative period, with matrix deposition initially exceeding, later equalling and finally lower than the rate of mineralization. The mineral appositional rate (MAR) was 1.2 microns/day and the adjusted mineral appositional rate (Aj.AR) 0.9 micron/day. Both MAR and Aj.AR decreased during the formative period. A completed wall thickness of 62 microns left a Haversian canal with a diameter of 29 microns. After a quiescent period of 438 days the osteon (or parts of it) was reactivated. The average activation frequency was 0.93 per year.
本文描述了对10名正常年轻个体的髂嵴皮质骨进行四环素双标记后，根据静态和动态变量重建其重塑周期的情况。吸收期的平均持续时间为27天，在此期间平均吸收速率为4.7微米/天。最终吸收深度为76微米。含破骨细胞的切割锥直径显著小于含单核细胞的切割锥（P小于0.05），这表明在单核吸收阶段之前存在一个初始破骨细胞吸收阶段。平均矿化延迟时间为8天，形成期为89天。在此期间类骨质厚度平均为5.8微米。缝厚度随下方未完成壁厚度而变化，即在形成期过程中，基质沉积最初超过、随后等于、最终低于矿化速率。矿化沉积速率（MAR）为1.2微米/天，调整后的矿化沉积速率（Aj.AR）为0.9微米/天。MAR和Aj.AR在形成期均下降。完整壁厚度为62微米，留下直径为29微米的哈弗斯管。在438天的静止期后，骨单位（或其部分）被重新激活。平均激活频率为每年0.93次。
