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本文引用的文献

1
What have the genomics ever done for the psychoses?精神疾病的基因组学研究有何成果？
Psychol Med. 2010 Apr;40(4):529-40. doi: 10.1017/S0033291709991139. Epub 2009 Oct 12.
2
Advancing a functional genomics for schizophrenia: psychopathological and cognitive phenotypes in mutants with gene disruption.推进精神分裂症的功能基因组学研究：基因敲除突变体的精神病理学和认知表型。
Brain Res Bull. 2010 Sep 30;83(3-4):162-76. doi: 10.1016/j.brainresbull.2009.09.010. Epub 2009 Oct 1.
3
Mice mutant for genes associated with schizophrenia: common phenotype or distinct endophenotypes?与精神分裂症相关基因发生突变的小鼠：共同表型还是不同的内表型？
Behav Brain Res. 2009 Dec 7;204(2):258-73. doi: 10.1016/j.bbr.2009.04.001.
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Common polygenic variation contributes to risk of schizophrenia and bipolar disorder.常见的多基因变异会增加患精神分裂症和双相情感障碍的风险。
Nature. 2009 Aug 6;460(7256):748-52. doi: 10.1038/nature08185. Epub 2009 Jul 1.
5
Rare chromosomal deletions and duplications increase risk of schizophrenia.罕见的染色体缺失和重复会增加患精神分裂症的风险。
Nature. 2008 Sep 11;455(7210):237-41. doi: 10.1038/nature07239. Epub 2008 Jul 30.
6
Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database.精神分裂症基因关联研究的系统荟萃分析与领域概述：SzGene数据库
Nat Genet. 2008 Jul;40(7):827-34. doi: 10.1038/ng.171.
7
Deconstructing schizophrenia: an overview of the use of endophenotypes in order to understand a complex disorder.解构精神分裂症：对内表型用于理解复杂疾病的概述。
Schizophr Bull. 2007 Jan;33(1):21-32. doi: 10.1093/schbul/sbl049. Epub 2006 Nov 6.
8
The endophenotype concept in psychiatry: etymology and strategic intentions.精神病学中的内表型概念：词源与战略意图。
Am J Psychiatry. 2003 Apr;160(4):636-45. doi: 10.1176/appi.ajp.160.4.636.

突变鼠模型：精神分裂症中精神病理学和病理生物学领域的表型关系。

Mutant mouse models: phenotypic relationships to domains of psychopathology and pathobiology in schizophrenia.

机构信息

Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, St Stephen's Green, Dublin 2, Ireland.

出版信息

Schizophr Bull. 2010 Mar;36(2):243-5. doi: 10.1093/schbul/sbq004. Epub 2010 Feb 12.

DOI:10.1093/schbul/sbq004
PMID:20154202
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2833133/
Abstract

The present series of review articles seeks to elaborate how current findings in mutant mice may inform on the relationship between candidate genes and individual psychopathological and pathobiological aspects of schizophrenia. Each of the authors focuses on an overlapping selection of both well-characterized and emergent candidate genes, as identified through association and linkage studies and/or via their involvement in putative pathophysiological mechanisms, particularly those relating to dopaminergic and glutamatergic processes.

摘要

本综述系列旨在详细阐述突变小鼠的当前研究结果如何为候选基因与精神分裂症的个体精神病理学和病理生物学方面之间的关系提供信息。每位作者都专注于通过关联和连锁研究以及/或通过它们参与潜在的病理生理机制（特别是与多巴胺能和谷氨酸能过程相关的机制）而确定的、经过充分特征描述的和新兴的候选基因的重叠选择。