突变鼠模型：精神分裂症中精神病理学和病理生物学领域的表型关系。
Mutant mouse models: phenotypic relationships to domains of psychopathology and pathobiology in schizophrenia.
机构信息
Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, St Stephen's Green, Dublin 2, Ireland.
出版信息
Schizophr Bull. 2010 Mar;36(2):243-5. doi: 10.1093/schbul/sbq004. Epub 2010 Feb 12.
Abstract
The present series of review articles seeks to elaborate how current findings in mutant mice may inform on the relationship between candidate genes and individual psychopathological and pathobiological aspects of schizophrenia. Each of the authors focuses on an overlapping selection of both well-characterized and emergent candidate genes, as identified through association and linkage studies and/or via their involvement in putative pathophysiological mechanisms, particularly those relating to dopaminergic and glutamatergic processes.
摘要
本综述系列旨在详细阐述突变小鼠的当前研究结果如何为候选基因与精神分裂症的个体精神病理学和病理生物学方面之间的关系提供信息。每位作者都专注于通过关联和连锁研究以及/或通过它们参与潜在的病理生理机制（特别是与多巴胺能和谷氨酸能过程相关的机制）而确定的、经过充分特征描述的和新兴的候选基因的重叠选择。
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What have the genomics ever done for the psychoses?精神疾病的基因组学研究有何成果？
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Advancing a functional genomics for schizophrenia: psychopathological and cognitive phenotypes in mutants with gene disruption.推进精神分裂症的功能基因组学研究：基因敲除突变体的精神病理学和认知表型。
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