Hennepin County Medical Center, Clinical Laboratories, 701 Park Avenue, Minneapolis, MN 55415, USA.
Am J Clin Pathol. 2010 Mar;133(3):447-53. doi: 10.1309/AJCP4X5VHFSOERFT.
Fentanyl concentrations were measured in postmortem specimens collected in 20 medical examiner cases from femoral blood (FB), heart blood (HB), heart tissue, liver tissue, and skeletal muscle. Unique was a subset of 7 cases in which FB was obtained at 2 postmortem intervals, shortly after death (FB1) and at autopsy (FB2). The mean collection times of FB1 and FB2 after death were 4.0 and 21.6 hours, respectively. Fentanyl concentrations for FB1 and FB2 ranged from undetectable to 14.6 microg/L (mean, 4.6 microg/L) and 2.0 to 52.5 microg/L (mean, 17.3 microg/L), respectively. Corresponding mean HB, liver tissue, and heart tissue fentanyl concentrations were 29.8 microg/L, 109.7 mg/kg, and 103.4 mg/kg, respectively. The fentanyl HB/FB1 ratio (mean, 8.39) was higher compared with the corresponding HB/FB2 ratio (mean, 3.48). These results suggest that postmortem redistribution of fentanyl can occur in FB.
在 20 例尸检案例中，从股动脉血（FB）、心血（HB）、心脏组织、肝组织和骨骼肌中采集了芬太尼浓度的标本。一个独特的亚组是 7 例案例，其中 FB 在死后 2 个时间点采集，即死亡后不久（FB1）和尸检时（FB2）。FB1 和 FB2 死后的平均采集时间分别为 4.0 和 21.6 小时。FB1 和 FB2 的芬太尼浓度范围从无法检测到 14.6 微克/升（平均 4.6 微克/升）和 2.0 到 52.5 微克/升（平均 17.3 微克/升）。相应的 HB、肝组织和心脏组织中芬太尼的平均浓度分别为 29.8 微克/升、109.7 毫克/千克和 103.4 毫克/千克。芬太尼 HB/FB1 比值（平均值 8.39）高于相应的 HB/FB2 比值（平均值 3.48）。这些结果表明，芬太尼可能会在 FB 中发生死后再分布。
