Seshimo Ken, Tanaka Noriaki, Yamashita Yutaka, Oishi Masahiro, Kodera Masahito, Yamamura Masao, Katoh Hiroshi, Ikeda Hideaki, Yokomichi Naosuke, Toshima Toshiaki, Kawai Yoshinari, Shibagaki Koutaro, Maejima Reijiro, Fujita Hiraku, Ichimura Kouichi, Takita Keiko
Dept. of Surgery, Tottori Municipal Hospital.
Gan To Kagaku Ryoho. 2010 Feb;37(2):319-21.
A 45-year-old male was admitted to our hospital complaining of anemia. Gastric endoscopy showed a type IIa+IIc tumor at the anterior wall of the gastric angle. Based on the pathology of the biopsy specimen, poorly-differentiated adenocarcinoma was diagnosed. Computed tomography scans showed regional lymph node swelling. Distal gastrectomy with a D2 lymph node dissection was performed. On pathology, the tumor was immunohistochemically positive for chromogranin A and synaptophysin. The Ki67 index was 70%. The tumor was diagnosed as poorly-differentiated neuroendocrine carcinoma of the stomach. He was treated with S-1 and CPT-11. Neuroendocrine cell carcinoma of the stomach is rare and usually has a very poor prognosis. Thus, we are reporting this case of early poorly-differentiated neuroendocrine carcinoma of the stomach that was curatively resected and had 12-month survival without recurrence.
一名45岁男性因贫血入院。胃镜检查显示胃角前壁有IIa+IIc型肿瘤。根据活检标本的病理结果，诊断为低分化腺癌。计算机断层扫描显示区域淋巴结肿大。行远端胃切除术及D2淋巴结清扫术。病理检查显示，肿瘤嗜铬粒蛋白A和突触素免疫组化呈阳性。Ki67指数为70%。该肿瘤被诊断为胃低分化神经内分泌癌。患者接受S-1和CPT-11治疗。胃神经内分泌细胞癌罕见，预后通常很差。因此，我们报告了这例早期胃低分化神经内分泌癌，经根治性切除后存活12个月且无复发。
