Miller B L, Lesser I M, Boone K B, Hill E, Mehringer C M, Wong K
Department of Neurology, Harbor-UCLA Medical Center, Torrance 90509.
Br J Psychiatry. 1991 Jan;158:76-82. doi: 10.1192/bjp.158.1.76.
Twenty-four patients who developed their first psychotic episode after the age of 45 were studied with MRI and comprehensive neuropsychological testing and compared with 72 healthy elderly subjects. The patients demonstrated more clinical abnormalities on MRI, were more likely to have large white-matter lesions or metabolic illness, and did more poorly on many neuropsychological tests, particularly those testing frontal-lobe and memory abilities. We conclude that structural brain injury is commonly associated with the late onset of psychosis. Neuroimaging investigations are a valuable component in the evaluation of this patient group.
对24名45岁以后首次出现精神病发作的患者进行了MRI检查和全面的神经心理学测试，并与72名健康的老年受试者进行了比较。这些患者在MRI上显示出更多的临床异常，更有可能有大面积的白质病变或代谢疾病，并且在许多神经心理学测试中表现更差，尤其是那些测试额叶和记忆能力的测试。我们得出结论，脑结构损伤通常与精神病的晚发有关。神经影像学检查是评估这一患者群体的重要组成部分。
