Wilson J T, Wiedmann K D, Hadley D M, Condon B, Teasdale G, Brooks D N
Experimental Neuropsychology Laboratory, Southern General Hospital, Glasgow, UK.
J Neurol Neurosurg Psychiatry. 1988 Mar;51(3):391-6. doi: 10.1136/jnnp.51.3.391.
Twenty five adults with closed head injury who had early magnetic resonance imaging (MRI) and computed tomography (CT) were followed up 5 to 18 months after injury. Patients were given a repeat MRI and performed a series of neuropsychological tests. They were classified by the deepest abnormality detectable on scanning. Classifications derived from early and late MRI scanning were significantly correlated. However, measures of neuropsychological outcome showed a strong correlation only with late MRI, and little or no relationship with either early MRI or early CT. Deeper abnormalities detected by late MRI were associated with poorer neuropsychological test performance; late ventricular enlargement was particularly associated with poor outcome. It is concluded that the lesions visualised by MRI are important for neuropsychological outcome, and that functionally significant abnormalities may only be fully apparent on late scanning.
对25名闭合性颅脑损伤的成年人进行了早期磁共振成像（MRI）和计算机断层扫描（CT）检查，并在受伤后5至18个月进行了随访。患者接受了重复MRI检查并进行了一系列神经心理学测试。根据扫描中可检测到的最深层异常对他们进行分类。早期和晚期MRI扫描得出的分类具有显著相关性。然而，神经心理学结果的测量仅与晚期MRI有很强的相关性，与早期MRI或早期CT几乎没有关系。晚期MRI检测到的更深层异常与较差的神经心理学测试表现相关；晚期脑室扩大尤其与不良预后相关。结论是，MRI显示的病变对神经心理学结果很重要，功能上显著的异常可能仅在晚期扫描时才完全显现出来。
