向外侧下丘脑或腹内侧下丘脑离子导入应用海藻酸后体重的性别依赖性变化。

Sex-dependent body weight changes after iontophoretic application of kainic acid into the LH or VMH.

作者信息

Lénárd L, Sándor P, Hajnal A, Jandó G, Karádi Z, Kai Y

机构信息

Hungarian Academy of Sciences, Institute of Physiology, University Medical School Pécs.

出版信息

Brain Res Bull. 1991 Jan;26(1):141-8. doi: 10.1016/0361-9230(91)90199-t.

DOI:10.1016/0361-9230(91)90199-t

PMID:2015510

Abstract

Body weight changes and food and water intakes were studied in CFY male and female rats after kainic acid (KA)-induced destruction of the lateral hypothalamic area (LH) or the ventromedial hypothalamic nucleus (VMH). To minimize the extent of damages, KA was iontophoretically applied by means of glass micropipettes. KA was ejected in 50 or 80 mM concentrations with 5-15 microA current for 5 min. Tip diameter of pipettes varied between 10-20 microns. Lesions were restricted to the LH or VMH. Effects were sex-dependent. LH lesions resulted in hypophagia, hypodipsia and body weight loss only in male rats. On the other hand, only female animals exhibited hyperphagia and weight increase when the VMH was destroyed. The role of sex-dependence in hypothalamic body weight regulation is discussed.

摘要

在使用 kainic 酸（KA）诱导损毁雄性和雌性 CFY 大鼠的外侧下丘脑区域（LH）或腹内侧下丘脑核（VMH）后，研究了它们的体重变化以及食物和水的摄入量。为了将损伤程度降至最低，通过玻璃微电极以离子电泳方式施加 KA。以 5 - 15 微安的电流，在 50 或 80 毫摩尔浓度下喷射 KA 5 分钟。电极尖端直径在 10 - 20 微米之间变化。损伤仅限于 LH 或 VMH。其影响具有性别依赖性。LH 损伤仅导致雄性大鼠出现摄食减少、饮水减少和体重减轻。另一方面，当 VMH 被损毁时，只有雌性动物表现出摄食过多和体重增加。本文讨论了性别依赖性在调节下丘脑体重方面的作用。