Research and Development, Ivoclar Vivadent, Schaan, Liechtenstein.
J Adhes Dent. 2010 Feb;12(1):7-10. doi: 10.3290/j.jad.a18439.
To demonstrate that hydrolytically stable methacrylamide monomers allow one-component self-etching adhesives with comparable adhesive properties and better storage stability than hitherto available methyacrylate-based adhesive formulations.
The shear bond strength and storage stability of the new one-component self-etching, methacrylamide-based adhesive AdheSE One F (Ivoclar Vivadent) to enamel and dentin was compared to the methacrylate-based Clearfil S3 Bond (Kuraray), G-Bond (GC), Hybrid Bond (Sun Medical), iBond (Heraeus Kulzer), Optibond All In One (Sybron-Kerr), and the methacrylamide-based Xeno V (Dentsply). Hydrolytic stability and adhesive performance of these adhesives was evaluated by accelerated aging at 42 degrees C over 16 weeks and monthly assessment of shear bond strength to dentin. The null hypothesis was that the bond strength of one-bottle self-etching dental adhesives is independent of storage duration and that, disregarding their higher stability against hydrolysis, methacrylamide- based materials offer performance beyond shelf-life time, comparable to methacrylate-based adhesives. Statistical analysis included 1-way-ANOVA and the Tukey-B post-hoc test (p < 0.05).
Shear bond strengths on enamel ranged from 32.7 MPa (AdheSE One F) to 16.6 MPa (iBond) and on dentin from 36.1 MPa (Optibond All In One) to 20.5 MPa (G-Bond). During accelerated aging, methacrylate-based adhesives with a pH < 2 exhibited decreasing bond strengths over time with material-dependent losses of up to 68% (Hybrid Bond, 8 weeks, 42 degrees C). Under the same conditions, the methacrylamide-based formulations AdheSE One F and Xeno V were stable for 16 weeks regarding shear bond strength to dentin.
The shelf life of one-component self-etching adhesives is determined by their chemical composition. In conventional methacrylate-based adhesives, the inherently acidic environment of such formulations leads to monomer degradation due to hydrolysis. In contrast, methacrylamide-based adhesives are stable to aqueous acid and exhibit much superior storage stability without monomer degradation-related losses in adhesion performance.
证明水解稳定的甲基丙烯酰胺单体可以制成具有类似粘结性能且储存稳定性优于现有甲基丙烯酸酯基粘结剂配方的单组份自酸蚀粘结剂。
比较新型单组份自酸蚀、甲基丙烯酰胺基粘结剂 AdheSE One F（义获嘉伟瓦登特）在牙釉质和牙本质上的剪切粘结强度和储存稳定性与基于甲基丙烯酸酯的 Clearfil S3 Bond（可乐丽）、G-Bond（GC）、Hybrid Bond（松风）、iBond（贺利氏古莎）、Optibond All In One（登士柏）和基于甲基丙烯酰胺的 Xeno V（登士柏）的粘结性能。通过在 42°C 下加速老化 16 周以及每月评估对牙本质的剪切粘结强度，评估这些粘结剂的水解稳定性和粘结性能。零假设是单瓶自酸蚀牙科粘结剂的粘结强度与储存时间无关，并且，尽管它们对水解的稳定性更高，但基于甲基丙烯酰胺的材料在保质期之外提供的性能与基于甲基丙烯酸酯的粘结剂相当。统计分析包括单向方差分析和 Tukey-B 事后检验（p < 0.05）。
牙釉质上的剪切粘结强度范围为 32.7 MPa（AdheSE One F）至 16.6 MPa（iBond），牙本质上的剪切粘结强度范围为 36.1 MPa（Optibond All In One）至 20.5 MPa（G-Bond）。在加速老化过程中，pH 值<2 的甲基丙烯酸酯基粘结剂随着时间的推移表现出粘结强度逐渐下降，材料依赖性损失高达 68%（Hybrid Bond，8 周，42°C）。在相同条件下，基于甲基丙烯酰胺的配方 AdheSE One F 和 Xeno V 在 16 周内对牙本质的剪切粘结强度保持稳定。
单组份自酸蚀粘结剂的保质期取决于其化学成分。在传统的甲基丙烯酸酯基粘结剂中，这种配方固有的酸性环境会导致单体因水解而降解。相比之下，基于甲基丙烯酰胺的粘结剂耐水性酸且具有优异的储存稳定性，不会因单体降解导致粘结性能损失。
