Department of Obstetrics and Gynaecology, The University of Hong Kong, Queen Mary Hospital and Tsan Yuk Hospital, 102 Pokfulam Road, Hong Kong, China.
Prenat Diagn. 2010 Apr;30(4):320-4. doi: 10.1002/pd.2455.
To compare the difference in maternal serum anti-Mullerian hormone (AMH) level between Down syndrome pregnancies and unaffected pregnancies, and to evaluate its performance as a screening marker for Down syndrome pregnancy.
A total of 145 pregnancies affected by foetal Down syndrome and 290 unaffected controls matched with maternal age and gestational age were selected, and their archived first or second trimester serum retrieved for AMH assay.
There was no significant difference in maternal serum AMH level between pregnancies affected and unaffected by foetal Down syndrome. Our first trimester serum samples had higher AMH concentration compared to second trimester samples.
Maternal serum AMH level, as a marker of ovarian age, is not superior to chronological age in predicting Down syndrome pregnancies. Despite the cross-sectional nature of our study, the variation of maternal serum AMH concentration with gestational age warrants further investigation.
比较唐氏综合征妊娠与非唐氏综合征妊娠孕妇血清抗苗勒管激素（AMH）水平的差异，评估其作为唐氏综合征妊娠筛查标志物的性能。
选择了 145 例唐氏综合征胎儿妊娠和 290 例年龄和孕周相匹配的非唐氏综合征胎儿妊娠孕妇，对其存档的孕早期或孕中期血清进行 AMH 检测。
唐氏综合征胎儿妊娠与非唐氏综合征胎儿妊娠孕妇血清 AMH 水平无显著差异。我们的孕早期血清样本的 AMH 浓度高于孕中期血清样本。
作为卵巢年龄标志物的血清 AMH 水平，在预测唐氏综合征妊娠方面并不优于年龄。尽管本研究为横断面研究，但母体血清 AMH 浓度随孕周的变化仍值得进一步研究。
