Clinical Immunohaematology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia.
Clin Infect Dis. 2010 Mar 15;50(6):e34-7. doi: 10.1086/650007.
We describe a unique case of fulminant infectious mononucleosis and recurrent Epstein-Barr virus reactivation presenting in an adolescent. Detailed assays of Epstein-Barr virus-specific T cell immunity revealed defects in the patient's T cell receptor signalling pathway characterized by a lack of interleukin-2 and CD25 expression, which may have contributed to her clinical course. Allogeneic stem cell transplantation reversed the clinical and laboratory phenotype.
我们描述了一例独特的青少年暴发性传染性单核细胞增多症和复发性 Epstein-Barr 病毒再激活病例。对 Epstein-Barr 病毒特异性 T 细胞免疫的详细检测显示，患者的 T 细胞受体信号通路存在缺陷，表现为缺乏白细胞介素 2 和 CD25 的表达，这可能导致了她的临床病程。异基因造血干细胞移植逆转了临床和实验室表型。
