Division of Gastroenterology, Tohoku University Graduate School of Medicine, Seiryo, Aobaku, Sendai, Japan.
Hepatol Res. 2010 Jan;40(1):61-8. doi: 10.1111/j.1872-034X.2009.00605.x.
Primary biliary cirrhosis (PBC) is characterized by unknown etiologies, anti-mitochondrial antibodies, injury of the biliary duct and the lack of a definite remedy. The etiologies of PBC have been well-discussed, including microorganisms and xenobiotics as the triggers for initiating the disease, and an abnormality of immune-tolerance. Recently, several animal models of PBC have been developed that may lead to the development of new therapies. Here, we reviewed the articles that address the etiology of PBC and the therapy for this disease for the confirmation of our current positions and future directions.
原发性胆汁性肝硬化（PBC）的特征为病因不明、抗线粒体抗体阳性、胆管损伤和缺乏明确的治疗方法。PBC 的病因已经得到了充分的讨论，包括微生物和外源性物质作为引发疾病的诱因，以及免疫耐受异常。最近，已经开发出几种 PBC 的动物模型，这可能会导致新疗法的发展。在这里，我们回顾了探讨 PBC 病因和该疾病治疗的文章，以确认我们目前的立场和未来的方向。
