Crit Care. 2010;14(1):112. doi: 10.1186/cc8199. Epub 2010 Feb 8.
Acute kidney injury (AKI) is now well recognized as an independent risk factor for increased morbidity and mortality, particularly when dialysis is needed. The wide variation in dialysis utilization contributes to a lack of consensus on what parameters should guide the decision to start dialysis. While the association of early initiation of dialysis with survival benefit was first demonstrated four decades ago, few studies in the modern era of dialysis have addressed time of dialysis initiation. Though listed as one of the top priorities in research on AKI, timing of dialysis initiation has not been included as a factor in any of the large, randomized controlled trials in this area.
急性肾损伤 (AKI) 现在被认为是增加发病率和死亡率的独立危险因素，尤其是在需要透析的情况下。透析利用率的广泛差异导致在应该指导开始透析的决策的参数方面缺乏共识。虽然早在四十年前就首次证明了早期开始透析与生存获益相关，但在现代透析时代，很少有研究涉及透析开始时间。尽管在 AKI 的研究中被列为首要任务之一，但在该领域的任何大型随机对照试验中，透析开始时间都未被列为一个因素。
