Department of Pharmacology, Columbia University, New York, New York 10032, USA.
Heart Rhythm. 2010 Aug;7(8):1151-3. doi: 10.1016/j.hrthm.2010.02.013. Epub 2010 Feb 13.
Increased cardiac output in response to beta-adrenergic receptor stimulation is achieved by rapid alteration of the activity of cardiac ion channels, pumps, and exchangers. Over the past decade, the discovery of macromolecular complexes, which include the ion channels and pumps and the kinases that control their level of phosphorylation, has led to an increased understanding of the molecular mechanisms behind the cardiac adrenergic response. The increased understanding has led to the discovery of a new long QT gene encoding an accessory protein in one of these macromolecular complexes. This article briefly reviews the major components of the beta-adrenergic pathway in the heart and discusses the direction of current and future research.
心脏对β肾上腺素能受体刺激的输出量增加是通过快速改变心脏离子通道、泵和交换器的活性来实现的。在过去的十年中，发现了包括离子通道和泵以及控制其磷酸化水平的激酶在内的大分子复合物，这使得人们对心脏肾上腺素能反应背后的分子机制有了更多的了解。这种深入的了解导致发现了一个新的长 QT 基因，该基因编码这些大分子复合物中的一个辅助蛋白。本文简要回顾了心脏中β肾上腺素能途径的主要组成部分，并讨论了当前和未来研究的方向。
