Department of Biochemistry, School of Medicine, Stanford University, Stanford, CA 94305, USA.
J Cell Biol. 2010 Feb 22;188(4):451-2. doi: 10.1083/jcb.201001121. Epub 2010 Feb 15.
In this issue, Duran et al. (2010. J. Cell Biol. doi: 10.1083/jcb.200911154) and Manjithaya et al. (2010. J. Cell Biol. doi: 10.1083/jcb.200911149) use yeast genetics to reveal a role for autophagosome intermediates in the unconventional secretion of an acyl coenzyme A (CoA)-binding protein that lacks an endoplasmic reticulum signal sequence. Medium-chain acyl CoAs are also required and may be important for substrate routing to this pathway.
在本期中，Duran 等人（2010. J. Cell Biol. doi: 10.1083/jcb.200911154）和 Manjithaya 等人（2010. J. Cell Biol. doi: 10.1083/jcb.200911149）利用酵母遗传学揭示了自噬体中间体在酰基辅酶 A（CoA）结合蛋白的非经典分泌中的作用，该蛋白缺乏内质网信号序列。中链酰基辅酶 A 也是必需的，并且可能对底物定向到该途径很重要。
Zotero 插件