Daly L
Department of Community Medicine and Epidemiology, University College, Dublin, Ireland.
Clin Exp Metastasis. 1991 Jan-Feb;9(1):3-11. doi: 10.1007/BF01831705.
Three hundred and forty-four patients with operable colorectal adenocarcinoma, Dukes' stage B or C, were entered into a randomized controlled trial of intraoperative and postoperative intravenous urokinase and/or long-term sodium warfarin therapy. The factorial design of the trial allowed evaluation of each therapy separately. Age, sex, Dukes' stage and cancer site were similar in the treatment groups. Using life-table methods, survival and recurrence/metastases free survival were estimated up to 6 years postoperatively. No significant effects of either therapy on these endpoints were found.
344例可手术切除的B期或C期结肠腺癌患者进入了一项关于术中及术后静脉注射尿激酶和/或长期使用华法林钠治疗的随机对照试验。该试验的析因设计允许分别评估每种治疗方法。各治疗组在年龄、性别、Dukes分期和癌症部位方面相似。采用寿命表法，对术后长达6年的生存率和无复发/转移生存率进行了评估。未发现这两种治疗方法对这些终点有显著影响。
