Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, China.
J Alzheimers Dis. 2010;19(3):927-35. doi: 10.3233/JAD-2010-1287.
Using statistical parametric mapping (SPM), we evaluate the feasibility and accuracy of (18) F -2-deoxy-2-fluoro-D-glucose (FDG) positron emission tomography (PET) for clinical diagnosis with characteristic hypo-metabolic regions, and examine the consistency of cerebral hypo-metabolism in Alzheimer's disease (AD) cross multicenters at both the group and the individual levels. Four groups of scan data including 39 AD patients and 52 healthy control subjects derived from three centers were analyzed and comparisons between patient subgroups or individual patient and relevant control population were performed using Two Sample T-test. In the group analysis, the hypo-metabolic regions of AD patients obtained from different PET centers were similar and consistent. The common hypo-metabolic cerebral areas were located bilaterally in the posterior cingulate and medial parietal cortex, temporo-parietal cortex, prefrontal cortex, and the middle and inferior temporal gyrus (uncorrected, p<0.001). In the analysis of each individual subject, the location of declined posterior cingulate and medial parietal cortex, temporo-parietal cortex and temporal lobe were found highly consistent with relevant characteristic regions obtained in the group analysis and were selected for diagnostic purposes. Complete typical hypo-metabolic pattern was observed in 67% and 54% of AD patients in two sets of 3D scans, respectively. Only 27% and 33.3% patients showed full typical pattern in two sets of 2D scans. The results indicated that FDG PET measures and SPM can 4 provide a valuable reference for clinical diagnosis of AD patients. The potential influence of acquisition mode on the clinical diagnosis of AD was suggested for further evaluation.
使用统计参数映射（SPM），我们评估了（18）F-2-脱氧-2-氟-D-葡萄糖（FDG）正电子发射断层扫描（PET）用于临床诊断的可行性和准确性，特征性低代谢区域，并在组和个体水平上检查了跨多中心阿尔茨海默病（AD）患者大脑低代谢的一致性。分析了来自三个中心的 39 名 AD 患者和 52 名健康对照者的四组扫描数据，并使用两样本 t 检验对患者亚组或个别患者与相关对照人群进行了比较。在组分析中，来自不同 PET 中心的 AD 患者的低代谢区域相似且一致。常见的低代谢大脑区域位于双侧后扣带回和内侧顶叶皮层、颞顶叶皮层、前额叶皮层以及中颞叶和下颞叶（未校正，p<0.001）。在对每个个体受试者的分析中，发现后扣带回和内侧顶叶皮层、颞顶叶皮层和颞叶的下降部位与组分析中获得的相关特征区域高度一致，并被选择用于诊断目的。在两组 3D 扫描中，分别有 67%和 54%的 AD 患者观察到完整的典型低代谢模式。在两组 2D 扫描中，只有 27%和 33.3%的患者表现出完整的典型模式。结果表明，FDG PET 测量和 SPM 可以为 AD 患者的临床诊断提供有价值的参考。建议进一步评估采集模式对 AD 临床诊断的潜在影响。
