University Department of Clinical Neurology, Level 3, West Wing, John Radcliffe Hospital, Oxford OX3 9DU, UK.
Nat Rev Neurol. 2010 Mar;6(3):156-66. doi: 10.1038/nrneurol.2010.1. Epub 2010 Feb 16.
Multiple sclerosis (MS) is a common, complex neurological disease. Epidemiological data implicate both genetic and environmental factors in the etiology of MS, with various factors interacting with one another. Environmental exposures might occur long before the disease becomes clinically evident, as suggested by the wide range in onset age. In this Review, we examine the key time periods during which the environment might contribute to MS susceptibility, as well as the potential environmental factors involved. Understanding the nature of environmental influences in MS is highly relevant to the development of public health measures that are aimed at preventing this debilitating disease.
多发性硬化症（MS）是一种常见的、复杂的神经系统疾病。流行病学数据表明，MS 的病因既有遗传因素，也有环境因素，而且各种因素相互作用。正如发病年龄范围很广所表明的那样，环境暴露可能早在疾病出现临床症状之前就已经发生。在这篇综述中，我们探讨了环境可能导致 MS 易感性的关键时期，以及可能涉及的潜在环境因素。了解 MS 中环境影响的性质对于制定旨在预防这种使人衰弱的疾病的公共卫生措施具有重要意义。
